Evidence map›Paper›PMID 33135631›Full record

ArticleeLife2020

Opposing JAK-STAT and Wnt signaling gradients define a stem cell domain by regulating differentiation at two borders.

David Melamed, Daniel Kalderon

Open access · goldAbstract read
In one paragraph

Article in eLife, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 24 citations in OpenAlex.

  1. Article
  2. Article
  3. Starve-Feed Cycles Direct Quiescence to Proliferation Transitions inbioRxiv : the preprint server for biology · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

David MelamedDepartment of Biological Sciences, Columbia University, New York, United States.ORCID 0000-0002-2102-1340
Daniel KalderonDepartment of Biological Sciences, Columbia University, New York, United States.ORCID 0000-0002-2149-0673
Columbia University · US

Funding

Somatic stem cells in the Drosophila ovaryR01GM079351 · NIGMS · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI DANIEL D KALDERON · 2009 to 2026
$5.8M
NIGMS NIH HHS R01 GM079351
6 · The paper itself

Abstract

Many adult stem cell communities are maintained by population asymmetry, where stochastic behaviors of multiple individual cells collectively result in a balance between stem cell division and differentiation. We investigated how this is achieved for

Indexed as

AnimalsCell DifferentiationDrosophila melanogasterGenotypeJanus KinasesSTAT Transcription FactorsStem CellsWnt ProteinsWnt Signaling PathwayJanus KinasesSTAT Transcription FactorsWnt Proteinsdevelopmental biologyD. melanogasterFollicle Stem CellsJAK-STATnicheregenerative medicinesignalingstem cellsStem CellsWnt

Identifiers

PMID33135631
PMCPMC7695452
OpenAlexW3097671383

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.