Evidence map›Paper›PMID 33135560›Full record

ArticleJournal of empirical research on human research ethics : JERHRE

Characterizing Current Attitudes and Practices for Human Subject Safety in Studies Involving Pupil Dilation.

Jacob Szpernal, Joseph Carroll, Ryan Spellecy, Jane A Bachman Groth

Open access · greenAbstract read
In one paragraph

Article in Journal of empirical research on human research ethics : JERHRE. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Jacob SzpernalSchool of Medicine, Medical College of Wisconsin, Milwaukee, USA.ORCID 0000-0002-2911-9158
Joseph CarrollDepartment of Ophthalmology & Visual Sciences, 5506Medical College of Wisconsin, Milwaukee, USA.ORCID 0000-0002-8640-1029
Ryan SpellecyCenter for Bioethics and Medical Humanities, Medical College of Wisconsin, Milwaukee, USA.
Jane A Bachman GrothDepartment of Ophthalmology & Visual Sciences, 5506Medical College of Wisconsin, Milwaukee, USA.
Medical College of Wisconsin · US

Funding

Clinical and Translational Science AwardUL1TR001436 · NCATS · MEDICAL COLLEGE OF WISCONSIN · PI FREED, JULIE K · 2015 to 2025
$47.5M
VISION RES LAB: HERPETIC KERATIC, CORE PIGMENT GENES, RETINITIS PIGMENTOSAC06RR016511 · NCRR · MEDICAL COLLEGE OF WISCONSIN · PI DUNN, MICHAEL J · 2002 to 2002
$1.4M
NCATS NIH HHS UL1 TR001436NCRR NIH HHS C06 RR016511
6 · The paper itself

Abstract

Standards in pupil dilation practices regarding the safety of human subjects are not present in vision research despite the potential for significant adverse effects. We developed two surveys to examine current practices around pupil dilation among vision researchers and individuals associated with oversight of human subjects research. While both groups note an absence of adverse events associated with pupil dilation, vision researcher practices differed with informed consent use and measures taken to minimize complications. For Institutional Review Boards, general risk assumption associated with dilation was not unanimous and there was a lack of specific guidance available to researchers for minimizing risk. These results uncover the need for standardized practices regarding pupil dilation in human subjects research.

Indexed as

Ethics Committees, ResearchPupilAttitudeHumansInformed ConsentResearch Subjectsconsentophthalmologyoptometrypupil dilationrisksafety

Identifiers

PMID33135560
PMCPMC8035129
OpenAlexW3097037547

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.