ArticleImmunity, inflammation and disease2020
Characterization and protective efficacy of a sptP mutant of Salmonella Paratyphi A.
Article in Immunity, inflammation and disease, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed.
- PipC affects the virulence ofFrontiers in microbiology · 2025Article
- Article
- Paratyphoid Fever A: Infection and Prevention.Frontiers in microbiology · 2022Review
- Characterization and protective efficacy of a sptP mutant of Salmonella Paratyphi A.Immunity, inflammation and disease · 2020Article
Corrections and comments
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Authors and funding
5 authors.
Funding
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Abstract
backgroundSalmonella Paratyphi A causes paratyphoid A, a severe systemic disease of people and remains a major public health problem in many parts of the world. In the interest of researching the roles of sptP on Salmonella Paratyphi A and developing a live-attenuated vaccine candidate, an sptP mutant of Salmonella Paratyphi A SPA017 (SPA017ΔsptP) was constructed, and then its characterization, immunogenicity, and protective ability were evaluated.
resultsThe deletion of sptP had no effect on growth and biochemical properties. Adhesion and invasion assays showed that the lack of sptP did not affect the adhesion of Salmonella Paratyphi A, but the invasive ability of the mutant strain was significantly decreased, the half-lethal dose (LD
conclusionsThese results demonstrated that SptP plays an essential role in the pathogenicity of Salmonella Paratyphi A, and Salmonella Paratyphi A lacking sptP is immunogenic and protective in mice.
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