Evidence map›Paper›PMID 33135334›Full record

ArticleFEBS open bio2021

Cardiac pericytes function as key vasoactive cells to regulate homeostasis and disease.

Linda L Lee, Aarif Y Khakoo, Vishnu Chintalgattu

Open access · goldAbstract read
In one paragraph

Article in FEBS open bio, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 24 citations in OpenAlex.

  1. Review
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  4. Vascular (dys)function in the failing heart.Nature reviews. Cardiology · 2025
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  13. A perspective on Notch signalling in progression and arrhythmogenesis in familial hypertrophic and dilated cardiomyopathies.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Linda L LeeDepartment of Cardiometabolic Disorders, Amgen Research and Discovery, Amgen Inc., South San Francisco, CA, USA.ORCID 0000-0001-7193-2460
Aarif Y KhakooDepartment of Drug Development, Calico Labs, South San Francisco, CA, USA.
Vishnu ChintalgattuDepartment of Cardiometabolic Disorders, Amgen Research and Discovery, Amgen Inc., South San Francisco, CA, USA.ORCID 0000-0002-4766-5400
Amgen (United States) · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pericytes (PCs)-mural cells that envelop endothelial cells (ECs) of microvessels-regulate tissue-specific vasculature development as well as maturation and maintenance of endothelial barrier integrity. However, little is known about their tissue-specific function in the heart. Specifically, the mechanism by which cardiac PCs constrict coronary capillaries remains undetermined. To gain insights into the function of cardiac PCs at the cellular level, we isolated NG2

Indexed as

AnimalsCapillary PermeabilityCell HypoxiaCells, CulturedCoronary CirculationDisease Models, AnimalEndothelial CellsEndothelium, VascularHumansHypoxia-Inducible Factor 1, alpha SubunitMaleMiceMyocardial ContractionMyocardial InfarctionMyocardiumNo-Reflow PhenomenonHif1a protein, mouseHypoxia-Inducible Factor 1, alpha Subunitcardiac pericyteheartpericytesperivascular cellsvascular biology

Identifiers

PMID33135334
PMCPMC7780101
OpenAlexW3097720362

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.