Evidence map›Paper›PMID 33135176›Full record

ArticleThe Journal of comparative neurology2021

OFF bipolar cell density varies by subtype, eccentricity, and along the dorsal ventral axis in the mouse retina.

Michael J Camerino, Ian J Engerbretson, Parker A Fife, Nathan B Reynolds, Mikel H Berria, Jamie R Doyle, Mellisa R Clemons, Michael D Gencarella, Bart G Borghuis, Peter G Fuerst

Abstract read
In one paragraph

Article in The Journal of comparative neurology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Michael J CamerinoDepartment of Biological Sciences, University of Idaho, Moscow, Idaho, USA.ORCID 0000-0002-3742-6000
Ian J EngerbretsonDepartment of Biological Sciences, University of Idaho, Moscow, Idaho, USA.
Parker A FifeDepartment of Biological Sciences, University of Idaho, Moscow, Idaho, USA.
Nathan B ReynoldsDepartment of Biological Sciences, University of Idaho, Moscow, Idaho, USA.
Mikel H BerriaDepartment of Biological Sciences, University of Idaho, Moscow, Idaho, USA.
Jamie R DoyleDepartment of Biological Sciences, University of Idaho, Moscow, Idaho, USA.
Mellisa R ClemonsDepartment of Biological Sciences, University of Idaho, Moscow, Idaho, USA.ORCID 0000-0001-5042-7115
Michael D GencarellaWWAMI Medical Education Program, University of Washington School of Medicine, Moscow, Idaho, USA.
Bart G BorghuisDepartment of Anatomical Sciences and Neurobiology, University of Louisville School of Medicine, Louisille, Kentuky, USA.
Peter G FuerstDepartment of Biological Sciences, University of Idaho, Moscow, Idaho, USA.ORCID 0000-0002-1671-0926

Funding

Women's health: interplay of maternal diet and key demographics on neurological health in the rural frontier and remote WestP20GM103408 · NIGMS · UNIVERSITY OF IDAHO · PI Carolyn Hovde Bohach · 2012 to 2026
$59.8M
Understanding signal processing in retinal bipolar cell pathwaysR01EY028188 · NEI · UNIVERSITY OF LOUISVILLE · PI BORGHUIS, BART GERARD · 2017 to 2021
$1.8M
OFF bipolar cell receptive field development and plasticityR21EY028297 · NEI · UNIVERSITY OF IDAHO · PI BORGHUIS, BART GERARD, FUERST, PETER GERARD · 2017 to 2018
$421k
NEI NIH HHS R01 EY028188NEI NIH HHS R21 EY028297NIGMS NIH HHS P20 GM103408
6 · The paper itself

Abstract

The neural retina is organized along central-peripheral, dorsal-ventral, and laminar planes. Cellular density and distributions vary along the central-peripheral and dorsal-ventral axis in species including primates, mice, fish, and birds. Differential distribution of cell types within the retina is associated with sensitivity to different types of damage that underpin major retinal diseases, including macular degeneration and glaucoma. Normal variation in retinal distribution remains unreported for multiple cell types in widely used research models, including mouse. Here we map the distribution of all known OFF bipolar cell (BC) populations and horizontal cells. We report significant variation in the distribution of OFF BC populations and horizontal cells along the dorsal-ventral and central-peripheral axes of the retina. Distribution patterns are much more pronounced for some populations of OFF BC cells than others and may correspond to the cell type's specialized functions.

Indexed as

AnimalsMiceRetinal Bipolar Cellsaxondendritedevelopmentgeneticsneuralneuronvision

Identifiers

PMID33135176
PMCPMC8009814

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.