Evidence map›Paper›PMID 33135149›Full record

ArticlePharmacoEconomics2021

Overlap of Depressive Symptoms with Health-Related Quality-of-Life Measures.

Ron D Hays, Peter M Fayers

Abstract read
In one paragraph

Article in PharmacoEconomics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. The association among psychological factors, pain severity and quality of life in people living beyond adolescent and young adult cancer: a systematic review and meta-analysis.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2026
    Pooled it
  3. Trial
  4. Heterogeneity of quality of life in the later stages of first-episode psychosis recovery.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2023
    Trial
  5. Predictors of quality of life after cardiac procedures: a mixed-methods study.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2026
    Article
  6. Article
  7. Article
  8. Health-related quality of life of unemployed individuals diagnosed with a mental illness: a cross-sectional study.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2025
    Article
  9. Article
  10. Article
  11. Article
  12. Quality of life dimensions in people living with mental disorders: moving beyond global scores.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2025
    Article
  13. Impact of sleep quality on health-related quality of life domains and the mediating effects of symptoms in people with multiple sclerosis.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2025
    Article
  14. Article
  15. Health-related quality of life in psychiatric outpatients: a cross-sectional study of associations with symptoms, diagnoses, and employment status.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2024
    Article
  16. Health-related quality of life and utility values among patients with anxiety and/or depression in a low-income tertiary care setting: a cross-sectional analysis.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2024
    Article
  17. Article
  18. Article
  19. Impact of episodic and chronic vestibular disorders on health-related quality of life and functioning-results from the DizzyReg patient registry.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2023
    Article
  20. Vision-related quality of life compared to generic measures in retinoblastoma survivors.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Ron D HaysDivision of General Internal Medicine and Health Services Research, Department of Medicine, UCLA, Los Angeles, CA, USA. drhays@ucla.edu.ORCID 0000-0001-6697-907X
Peter M FayersInstitute of Applied Health Sciences, King's College, University of Aberdeen, Aberdeen, UK.

Funding

The Center for Health Improvement of Minority ElderlyP30AG021684 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Homero Erwin del Pino · 2002 to 2026
$19.7M
NIA NIH HHS P30 AG021684
6 · The paper itself

Abstract

Because depressive symptoms are a part of health-related quality-of-life (HRQOL) measures, measures of depression will be empirically associated with HRQOL. We discuss examples of published research where authors ignored or did not fully account for overlap between depressive symptom and HRQOL measures. Future researchers need to recognize when their models include conceptually similar variables on the same side or both sides of the equation. This awareness will lead to more accurate conclusions about the prognostic value of depression and other HRQOL measures for health care utilization, mortality, and other outcomes. It will also result in fewer incorrect claims about the effect of depression on HRQOL.

Indexed as

DepressionQuality of LifeHumansPatient Acceptance of Health CareSurveys and Questionnaires

Identifiers

PMID33135149
PMCPMC8088445

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.