ArticleSchizophrenia bulletin2021
Disrupted Intersubject Variability Architecture in Functional Connectomes in Schizophrenia.
Article in Schizophrenia bulletin, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Subtypes of adolescent major depressive disorder characterized by divergent information dynamics in sensory-association cortices.Nature communications · 2026Article
- Deciphering the Heterogeneity of Schizophrenia: A Multimodal and Multivariate Neuroimaging Framework for Unveiling Brain-Symptom Relationships and Underlying Subtypes.Schizophrenia bulletin · 2026Article
- Altered Brain Network Dynamics in Schizophrenia Patients With Predominant Negative Symptoms: A Resting-State fMRI Study Using Co-Activation Pattern Analysis.Human brain mapping · 2025Article
- Exploring Heterogeneity in Vestibular Migraine Using Individualized Differential Structural Covariance Network Analysis.CNS neuroscience & therapeutics · 2025Article
- Resolving heterogeneity in first-episode and drug-naive major depressive disorder based on individualized structural covariance network: evidence from the REST-meta-MDD consortium.Psychological medicine · 2025Article
- Enhanced individual difference of functional brain network induced by volitional eyes closing.Scientific reports · 2025Article
- Increased individual variability in functional connectivity of the default mode network and its genetic correlates in major depressive disorder.Scientific reports · 2025Article
- Schizophrenia and Neurodevelopment: Insights From Connectome Perspective.Schizophrenia bulletin · 2025Review
- Physical illness in schizophrenia and the role of tolerability in antipsychotic selection: an expert consensus with a focus on cariprazine.Annals of general psychiatry · 2025Review
- Disrupted intersubject variability architecture in structural and functional brain connectomes in major depressive disorder.Psychological medicine · 2025Article
- Abnormal gray matter volume and structural covariance network of basal ganglia-limbic system in patients with major depression disorder.Frontiers in neurology · 2025Article
- Altered intersubject functional variability of brain white-matter in major depressive disorder and its association with gene expression profiles.Human brain mapping · 2024Article
- Age-related decrease in inter-subject similarity of cortical morphology and task and resting-state functional connectivity.GeroScience · 2024Article
- Increased whole-brain functional heterogeneity in psychosis during rest and task.NeuroImage. Clinical · 2024Article
- Robust hierarchically organized whole-brain patterns of dysconnectivity in schizophrenia spectrum disorders observed after personalized intrinsic network topography.Human brain mapping · 2023Article
- Exploring the role of hub and network dysfunction in brain connectomes of schizophrenia using functional magnetic resonance imaging.Frontiers in psychiatry · 2023Article
- Two distinct subtypes of obsessive compulsive disorder revealed by a framework integrating multimodal neuroimaging information.Human brain mapping · 2022Article
- Two distinct subtypes of obsessive compulsive disorder revealed by heterogeneity through discriminative analysis.Human brain mapping · 2022Article
- Higher brain structural heterogeneity in schizophrenia.Frontiers in psychiatry · 2022Article
- Transcriptomic and macroscopic architectures of intersubject functional variability in human brain white-matter.Communications biology · 2021Article
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Authors and funding
12 authors.
Funding
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Abstract
Schizophrenia (SCZ) is a highly heterogeneous disorder with remarkable intersubject variability in clinical presentations. Previous neuroimaging studies in SCZ have primarily focused on identifying group-averaged differences in the brain connectome between patients and healthy controls (HCs), largely neglecting the intersubject differences among patients. We acquired whole-brain resting-state functional MRI data from 121 SCZ patients and 183 HCs and examined the intersubject variability of the functional connectome (IVFC) in SCZ patients and HCs. Between-group differences were determined using permutation analysis. Then, we evaluated the relationship between IVFC and clinical variables in SCZ. Finally, we used datasets of patients with bipolar disorder (BD) and major depressive disorder (MDD) to assess the specificity of IVFC alteration in SCZ. The whole-brain IVFC pattern in the SCZ group was generally similar to that in HCs. Compared with the HC group, the SCZ group exhibited higher IVFC in the bilateral sensorimotor, visual, auditory, and subcortical regions. Moreover, altered IVFC was negatively correlated with age of onset, illness duration, and Brief Psychiatric Rating Scale scores and positively correlated with clinical heterogeneity. Although the SCZ shared altered IVFC in the visual cortex with BD and MDD, the alterations of IVFC in the sensorimotor, auditory, and subcortical cortices were specific to SCZ. The alterations of whole-brain IVFC in SCZ have potential implications for the understanding of the high clinical heterogeneity of SCZ and the future individualized clinical diagnosis and treatment of this disease.
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