ArticleCritical care explorations2020
Volatile Isoflurane in Critically Ill Coronavirus Disease 2019 Patients-A Case Series and Systematic Review.
Article in Critical care explorations, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 30 citations in OpenAlex.
- Volatile versus propofol sedation after cardiac valve surgery: a single-center prospective randomized controlled trial.Critical care (London, England) · 2024Trial
- Costs and Arising Work Times of Volatile Short-Term Sedation in Intensive Care.Healthcare (Basel, Switzerland) · 2025Article
- Impact of Respiratory Support During Hospitalization on Functional Outcomes in Long COVID: A Post-Hoc Analysis of a Prospective Cohort Study.International journal of environmental research and public health · 2024Article
- Inhaled volatile anesthetics in the intensive care unit.World journal of critical care medicine · 2024Review
- Sedation for Patients with Sepsis: Towards a Personalised Approach.Journal of personalized medicine · 2023Review
- Sedation with Sevoflurane versus Propofol in COVID-19 Patients with Acute Respiratory Distress Syndrome: Results from a Randomized Clinical Trial.Journal of personalized medicine · 2023Article
- Sedation with volatile anesthetics in the intensive care unit: a new option with old agents.Critical care science · 2023Article
- Usefulness of Inhaled Sedation in Patients With Severe ARDS Due to COVID-19.Respiratory care · 2023Article
- Inhaled Sedation with Volatile Anesthetics for Mechanically Ventilated Patients in Intensive Care Units: A Narrative Review.Journal of clinical medicine · 2023Review
- Inhaled Sedation in Patients with COVID-19-Related Acute Respiratory Distress Syndrome: An International Retrospective Study.Journal of clinical medicine · 2022Article
- Metformin alleviates prolonged isoflurane inhalation induced cognitive decline via reducing neuroinflammation in adult mice.International immunopharmacology · 2022Article
- Electroencephalogram-Based Evaluation of Impaired Sedation in Patients with Moderate to Severe COVID-19 ARDS.Journal of clinical medicine · 2022Article
- Inhaled Sedation for Invasively Ventilated COVID-19 Patients: A Systematic Review.Journal of clinical medicine · 2022Review
- Article
- Associated Factors of High Sedative Requirements within Patients with Moderate to Severe COVID-19 ARDS.Journal of clinical medicine · 2022Article
- Use of volatile anesthetics for sedation in the ICU during the COVID-19 pandemic: A national survey in France (VOL'ICU 2 study).PloS one · 2022Article
- Druggable targets and therapeutic development for COVID-19.Frontiers in chemistry · 2022Review
- Extracorporeal membrane oxygenation and inhaled sedation in coronavirus disease 2019-related acute respiratory distress syndrome.World journal of critical care medicine · 2021Review
- Anaesthesia-related drugs and SARS-CoV-2 infection.British journal of anaesthesia · 2021Article
- Standard Sedation and Sedation With Isoflurane in Mechanically Ventilated Patients With Coronavirus Disease 2019.Critical care explorations · 2021Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThe ongoing coronavirus pandemic is challenging, especially in severely affected patients who require intubation and sedation. Although the potential benefits of sedation with volatile anesthetics in coronavirus disease 2019 patients are currently being discussed, the use of isoflurane in patients with coronavirus disease 2019-induced acute respiratory distress syndrome has not yet been reported.
designWe performed a retrospective analysis of critically ill patients with hypoxemic respiratory failure requiring mechanical ventilation.
settingThe study was conducted with patients admitted between April 4 and May 15, 2020 to our ICU. PATIENTS: We included five patients who were previously diagnosed with severe acute respiratory syndrome coronavirus 2 infection.
interventionEven with high doses of several IV sedatives, the targeted level of sedation could not be achieved. Therefore, the sedation regimen was switched to inhalational isoflurane. Clinical data were recorded using a patient data management system. We recorded demographical data, laboratory results, ventilation variables, sedative dosages, sedation level, prone positioning, duration of volatile sedation and outcomes. MEASUREMENTS & MAIN
resultsMean age (four men, one women) was 53.0 (± 12.7) years. The mean duration of isoflurane sedation was 103.2 (± 66.2) hours. Our data demonstrate a substantial improvement in the oxygenation ratio when using isoflurane sedation. Deep sedation as assessed by the Richmond Agitation and Sedation Scale was rapidly and closely controlled in all patients, and the subsequent discontinuation of IV sedation was possible within the first 30 minutes. No adverse events were detected.
conclusionsOur findings demonstrate the feasibility of isoflurane sedation in five patients suffering from severe coronavirus disease 2019 infection. Volatile isoflurane was able to achieve the required deep sedation and reduced the need for IV sedation.
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