ArticleCerebral cortex communications2020
Structural Disconnection of the Tool Use Network after Left Hemisphere Stroke Predicts Limb Apraxia Severity.
Article in Cerebral cortex communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 36 citations in OpenAlex.
- Causal dependencies between frontal and temporal lobe regions underlying word search and retrieval.bioRxiv : the preprint server for biology · 2026Article
- Visual processing of manipulable objects in the ventral stream is modulated by parietal action systems.Brain communications · 2026Article
- Causal Lesion Evidence for Two Motor Speech Coordination Networks in the Brain.bioRxiv : the preprint server for biology · 2025Article
- Differential Lesion Patterns Associated With Stroke-Induced Apraxia in Women and Men.European journal of neurology · 2025Article
- Using mechanistic knowledge to appraise contemporary approaches to the rehabilitation of upper limb function following stroke.The Journal of physiology · 2025Review
- Left-hemisphere glioma drives systematic patterns of contralesional functional connectivity.Brain communications · 2025Article
- Distorted time window for sensorimotor integration and preserved time window for sense of agency in patients with post-stroke limb apraxia.Frontiers in human neuroscience · 2025Article
- A preliminary study of white matter disconnections underlying deficits in praxis in left hemisphere stroke patients.Brain structure & function · 2024Article
- Apraxia: From Neuroanatomical Pathways to Clinical Manifestations.Current neurology and neuroscience reports · 2024Review
- The "What" and "How" of Pantomime Actions.Vision (Basel, Switzerland) · 2024Review
- Voxel-Based Lesion Analysis of Ideomotor Apraxia.Brain sciences · 2024Article
- Mechanisms and neuroanatomy of response selection in tool and non-tool action tasks: Evidence from left-hemisphere stroke.Cortex; a journal devoted to the study of the nervous system and behavior · 2023Article
- Association of Circumscribed Subcortical Gray and White Matter Lesions With Apraxic Deficits in Patients With Left Hemisphere Stroke.Neurology · 2023Article
- Left anterior supramarginal gyrus activity during tool use action observation after extensive tool use training.Experimental brain research · 2023Article
- Shared and distinct routes in speech and gesture imitation: Evidence from stroke.Cortex; a journal devoted to the study of the nervous system and behavior · 2023Article
- Mapping lesion, structural disconnection, and functional disconnection to symptoms in semantic aphasia.Brain structure & function · 2022Article
- Brain intrinsic connection patterns underlying tool processing in human adults are present in neonates and not in macaques.NeuroImage · 2022Article
- Single-case disconnectome lesion-symptom mapping: Identifying two subtypes of limb apraxia.Neuropsychologia · 2022Article
- Does spatial perspective in virtual reality affect imitation accuracy in stroke patients?Frontiers in virtual reality · 2022Article
- Mapping the human praxis network: an investigation of white matter disconnection in limb apraxia of gesture production.Brain communications · 2022Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
Producing a tool use gesture is a complex process drawing upon the integration of stored knowledge of tools and their associated actions with sensory-motor mechanisms supporting the planning and control of hand and arm actions. Understanding how sensory-motor systems in parietal cortex interface with semantic representations of actions and objects in the temporal lobe remains a critical issue and is hypothesized to be a key determinant of the severity of limb apraxia, a deficit in producing skilled action after left hemisphere stroke. We used voxel-based and connectome-based lesion-symptom mapping with data from 57 left hemisphere stroke participants to assess the lesion sites and structural disconnection patterns associated with poor tool use gesturing. We found that structural disconnection among the left inferior parietal lobule, lateral and ventral temporal cortices, and middle and superior frontal gyri predicted the severity of tool use gesturing performance. Control analyses demonstrated that reductions in right-hand grip strength were associated with motor system disconnection, largely bypassing regions supporting tool use gesturing. Our findings provide evidence that limb apraxia may arise, in part, from a disconnection between conceptual representations in the temporal lobe and mechanisms enabling skilled action production in the inferior parietal lobule.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.