Evidence map›Paper›PMID 33134609›Full record

ArticleBioactive materials2021

Azacarbazole n-3 and n-6 polyunsaturated fatty acids ethyl esters nanoemulsion with enhanced efficacy against

Anna Jaromin, Silvia Parapini, Nicoletta Basilico, Magdalena Zaremba-Czogalla, Agnieszka Lewińska, Agnieszka Zagórska, Maria Walczak, Bożena Tyliszczak, Aleksandra Grzeszczak, Marcin Łukaszewicz and 2 more

Open access · goldAbstract read
In one paragraph

Article in Bioactive materials, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.8field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. Autophagy-Mediated Suppression of Tumor Growth by Food-Grade Lipid Nanoparticles in Mice.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 2 countries.

Anna JarominDepartment of Lipids and Liposomes, Faculty of Biotechnology, University of Wroclaw, Wroclaw, Poland.
Silvia ParapiniDipartimento di Scienze Biomediche per la Salute, Università degli Studi di Milano, Milan, Italy.
Nicoletta BasilicoDipartimento di Scienze Biomediche, Chirurgiche e Odontoiatriche, Università degli Studi di Milano, Milan, Italy.
Magdalena Zaremba-CzogallaDepartment of Lipids and Liposomes, Faculty of Biotechnology, University of Wroclaw, Wroclaw, Poland.
Agnieszka LewińskaFaculty of Chemistry, University of Wroclaw, Wroclaw, Poland.
Agnieszka ZagórskaDepartment of Medicinal Chemistry, Jagiellonian University Medical College, Cracow, Poland.
Maria WalczakChair and Department of Toxicology, Jagiellonian University Medical College, Faculty of Pharmacy, Cracow, Poland.
Bożena TyliszczakInstytute of Materials Science, Cracow University of Technology, Cracow, Poland.
Aleksandra GrzeszczakDepartment of Lipids and Liposomes, Faculty of Biotechnology, University of Wroclaw, Wroclaw, Poland.
Marcin ŁukaszewiczDepartment of Biotransformation, Faculty of Biotechnology, University of Wroclaw, Wroclaw, Poland.
Łukasz KaczmarekPharmaceutical Research Institute, Warsaw, Poland.
Jerzy GubernatorDepartment of Lipids and Liposomes, Faculty of Biotechnology, University of Wroclaw, Wroclaw, Poland.
University of Wrocław · PLJagiellonian University · PLUniversity of Milan · ITCracow University of Technology · PLInstytut Farmaceutyczny · PL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Alternative therapies are necessary for the treatment of malaria due to emerging drug resistance. However, many promising antimalarial compounds have poor water solubility and suffer from the lack of suitable delivery systems, which seriously limits their activity. To address this problem, we synthesized a series of azacarbazoles that were evaluated for antimalarial activity against D10 (chloroquine-sensitive) and W2 (chloroquine-resistant) strains of

Indexed as

AzacarbazolesFlax oilMalarian-3 and n-6 polyunsaturated fatty acids ethyl estersNanoemulsionP. falciparum

Identifiers

PMID33134609
PMCPMC7588843
OpenAlexW3094609556

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.