Evidence map›Paper›PMID 33134608›Full record

ArticleBioactive materials2021

Viscosity and degradation controlled injectable hydrogel for esophageal endoscopic submucosal dissection.

Chaoqiang Fan, Kaige Xu, Yu Huang, Shuang Liu, Tongchuan Wang, Wei Wang, Weichao Hu, Lu Liu, Malcolm Xing, Shiming Yang

Erratum issuedOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioactive materials, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
3.4field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 68 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Chaoqiang FanDepartment of Gastroenterology, Xinqiao Hospital, Army Medical University, NO.183, Xinqiao Street, Shapingba District, Chongqing City, 400037, People's Republic of China.
Kaige XuDepartment of Mechanical Engineering, Biochemistry and Medical Genetics, University of Manitoba, Winnipeg MB, R3T 2N2, Manitoba, Canada.
Yu HuangDepartment of Gastroenterology, Xinqiao Hospital, Army Medical University, NO.183, Xinqiao Street, Shapingba District, Chongqing City, 400037, People's Republic of China.
Shuang LiuDepartment of Gastroenterology, Xinqiao Hospital, Army Medical University, NO.183, Xinqiao Street, Shapingba District, Chongqing City, 400037, People's Republic of China.
Tongchuan WangDepartment of Gastroenterology, Xinqiao Hospital, Army Medical University, NO.183, Xinqiao Street, Shapingba District, Chongqing City, 400037, People's Republic of China.
Wei WangDepartment of Gastroenterology, Xinqiao Hospital, Army Medical University, NO.183, Xinqiao Street, Shapingba District, Chongqing City, 400037, People's Republic of China.
Weichao HuDepartment of Gastroenterology, Xinqiao Hospital, Army Medical University, NO.183, Xinqiao Street, Shapingba District, Chongqing City, 400037, People's Republic of China.
Lu LiuDepartment of Gastroenterology, Xinqiao Hospital, Army Medical University, NO.183, Xinqiao Street, Shapingba District, Chongqing City, 400037, People's Republic of China.
Malcolm XingDepartment of Mechanical Engineering, Biochemistry and Medical Genetics, University of Manitoba, Winnipeg MB, R3T 2N2, Manitoba, Canada.
Shiming YangDepartment of Gastroenterology, Xinqiao Hospital, Army Medical University, NO.183, Xinqiao Street, Shapingba District, Chongqing City, 400037, People's Republic of China.
Xinqiao Hospital · CNArmy Medical University · CNUniversity of Manitoba · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Endoscopic submucosal dissection (ESD) is a common procedure to treat early and precancerous gastrointestinal lesions. Via submucosal injection, a liquid cushion is created to lift and separate the lesion and malignant part from the muscular layer where the formed indispensable space is convenient for endoscopic incision. Saline is a most common submucosal injection liquid, but the formed liquid pad lasts only a short time, and thus repeated injections increase the potential risk of adverse events. Hydrogels with high osmotic pressure and high viscosity are used as an alternate; however, with some drawbacks such as tissue damage, excessive injection resistance, and high cost. Here, we reported a nature derived hydrogel of gelatin-oxidized alginate (G-OALG). Based on the rheological analysis and compare to commercial endoscopic mucosal resection (EMR) solution (0.25% hyaluronic acid, HA), a designed G-OALG hydrogel of desired concentration and composition showed higher performances in controllable gelation and injectability, higher viscosity and more stable structures. The G-OALG gel also showed lower propulsion resistance than 0.25% HA in the injection force assessment under standard endoscopic instruments, which eased the surgical operation. In addition, the G-OALG hydrogel showed good

Indexed as

Controllable gelation and viscosityEarly esophageal cancerEsophageal submucosal liquid cushionInjectable hydrogelPig model

Identifiers

PMID33134608
PMCPMC7588753
OpenAlexW3093549841

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.