Evidence map›Paper›PMID 33134510›Full record

ArticleNeurology. Genetics2020

Integrative analysis identifies the association between

Xing-Bo Mo, Huan Zhang, Ai-Li Wang, Tan Xu, Yong-Hong Zhang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurology. Genetics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 2 pooled it
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 2 syntheses or guidelines pooled it, 16 citations in OpenAlex.

  1. Accelerated epigenetic age in hypertension: a systematic review and meta-analysis.Hypertension research : official journal of the Japanese Society of Hypertension · 2026
    Pooled it
  2. Pooled it
  3. Article
  4. Review
  5. Biomedicines · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Xing-Bo MoJiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases (X.-B.M., H.Z., A.-L.W., T.X., Y-.H.Z.); Center for Genetic Epidemiology and Genomics (X.-B.M.); and Department of Epidemiology (X.-B.M., H.Z., A.-L.W., T.X., Y.-H.Z.), School of Public Health, Soochow University, Suzhou, Jiangsu, P. R. China.
Huan ZhangJiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases (X.-B.M., H.Z., A.-L.W., T.X., Y-.H.Z.); Center for Genetic Epidemiology and Genomics (X.-B.M.); and Department of Epidemiology (X.-B.M., H.Z., A.-L.W., T.X., Y.-H.Z.), School of Public Health, Soochow University, Suzhou, Jiangsu, P. R. China.
Ai-Li WangJiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases (X.-B.M., H.Z., A.-L.W., T.X., Y-.H.Z.); Center for Genetic Epidemiology and Genomics (X.-B.M.); and Department of Epidemiology (X.-B.M., H.Z., A.-L.W., T.X., Y.-H.Z.), School of Public Health, Soochow University, Suzhou, Jiangsu, P. R. China.
Tan XuJiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases (X.-B.M., H.Z., A.-L.W., T.X., Y-.H.Z.); Center for Genetic Epidemiology and Genomics (X.-B.M.); and Department of Epidemiology (X.-B.M., H.Z., A.-L.W., T.X., Y.-H.Z.), School of Public Health, Soochow University, Suzhou, Jiangsu, P. R. China.
Yong-Hong ZhangJiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases (X.-B.M., H.Z., A.-L.W., T.X., Y-.H.Z.); Center for Genetic Epidemiology and Genomics (X.-B.M.); and Department of Epidemiology (X.-B.M., H.Z., A.-L.W., T.X., Y.-H.Z.), School of Public Health, Soochow University, Suzhou, Jiangsu, P. R. China.
Soochow University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo highlight potential epigenetic risk factors for blood pressure (BP) and ischemic stroke (IS) in loci identified by genome-wide association studies (GWASs).

methodsWe detected DNA methylation for BP (317,756 individuals from UK Biobank) and IS (521,612 individuals from MEGASTROKE) in Europeans by using the summary data-based mendelian randomization (SMR) method. We selected the most relevant gene to validate the association in 1,207 patients with hypertensive IS and 1,269 controls from the Chinese populations.

resultsWe first identified 173 CpG sites in 90 genes, 337 CpG sites in 142 genes, and 9 CpG sites in 7 genes that were significantly associated with systolic, diastolic BP, and IS, respectively. The methylation level of cg12760995 in

conclusionsThis study identified DNA methylations that were associated with BP and IS.

Identifiers

PMID33134510
PMCPMC7577558
OpenAlexW3082399161

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.