Evidence map›Paper›PMID 33134509›Full record

ArticleNeurology. Genetics2020

Matrix metalloproteinase-degraded type I collagen is associated with

Man-Hung Eric Tang, Joseph P M Blair, Cecilie Liv Bager, Anne-Christine Bay-Jensen, Kim Henriksen, Claus Christiansen, Morten Asser Karsdal

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurology. Genetics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.4field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 13 citations in OpenAlex.

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  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Man-Hung Eric TangProScion (M.-H.E.T., J.P.M.B., C.L.B.), Herlev; Faculty of Health and Medical Sciences (J.P.M.B.), University of Copenhagen; ImmunoScience (A.-C.B.-J., C.C., M.A.K.), and Endocrinology (K.H.), Nordic Bioscience, Biomarkers and Research, Herlev, Denmark.ORCID 0000-0002-3483-0219
Joseph P M BlairProScion (M.-H.E.T., J.P.M.B., C.L.B.), Herlev; Faculty of Health and Medical Sciences (J.P.M.B.), University of Copenhagen; ImmunoScience (A.-C.B.-J., C.C., M.A.K.), and Endocrinology (K.H.), Nordic Bioscience, Biomarkers and Research, Herlev, Denmark.ORCID 0000-0003-3248-7039
Cecilie Liv BagerProScion (M.-H.E.T., J.P.M.B., C.L.B.), Herlev; Faculty of Health and Medical Sciences (J.P.M.B.), University of Copenhagen; ImmunoScience (A.-C.B.-J., C.C., M.A.K.), and Endocrinology (K.H.), Nordic Bioscience, Biomarkers and Research, Herlev, Denmark.ORCID 0000-0003-2430-9777
Anne-Christine Bay-JensenProScion (M.-H.E.T., J.P.M.B., C.L.B.), Herlev; Faculty of Health and Medical Sciences (J.P.M.B.), University of Copenhagen; ImmunoScience (A.-C.B.-J., C.C., M.A.K.), and Endocrinology (K.H.), Nordic Bioscience, Biomarkers and Research, Herlev, Denmark.
Kim HenriksenProScion (M.-H.E.T., J.P.M.B., C.L.B.), Herlev; Faculty of Health and Medical Sciences (J.P.M.B.), University of Copenhagen; ImmunoScience (A.-C.B.-J., C.C., M.A.K.), and Endocrinology (K.H.), Nordic Bioscience, Biomarkers and Research, Herlev, Denmark.
Claus ChristiansenProScion (M.-H.E.T., J.P.M.B., C.L.B.), Herlev; Faculty of Health and Medical Sciences (J.P.M.B.), University of Copenhagen; ImmunoScience (A.-C.B.-J., C.C., M.A.K.), and Endocrinology (K.H.), Nordic Bioscience, Biomarkers and Research, Herlev, Denmark.
Morten Asser KarsdalProScion (M.-H.E.T., J.P.M.B., C.L.B.), Herlev; Faculty of Health and Medical Sciences (J.P.M.B.), University of Copenhagen; ImmunoScience (A.-C.B.-J., C.C., M.A.K.), and Endocrinology (K.H.), Nordic Bioscience, Biomarkers and Research, Herlev, Denmark.
University of Copenhagen · DK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveDysregulation of type I collagen metabolism has a great impact on human health. We have previously seen that matrix metalloproteinase-degraded type I collagen (C1M) is associated with early death and age-related pathologies. To dissect the biological impact of type I collagen dysregulation, we have performed a genome-wide screening of the genetic factors related to type I collagen turnover.

methodsPatient registry data and genotypes have been collected for a total of 4,981 Danish postmenopausal women. Genome-wide association with serum levels of C1M was assessed and phenotype-genotype association analysis performed.

resultsTwenty-two genome-wide significant variants associated with C1M were identified in the

conclusionsOur study provides elements for better understanding the role of the collagen metabolism in the onset of cognitive impairment.

Identifiers

PMID33134509
PMCPMC7577557
OpenAlexW3084232510

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.