Evidence map›Paper›PMID 33134488›Full record

ArticleTransplantation direct2020

Increase in Alcoholic Hepatitis as an Etiology for Liver Transplantation in the United States: A 2004-2018 Analysis.

Nabil Noureddin, Ju Dong Yang, Naim Alkhouri, Samantha M Noreen, Alice E Toll, Tsuyoshi Todo, Walid Ayoub, Alexander Kuo, Georgios Voidonikolas, Honore G Kotler and 11 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Transplantation direct, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Nabil NoureddinSchool of Medicine, Department of Internal Medicine, University of Nevada, Las Vegas, Las Vegas, NV.
Ju Dong YangDivision of Digestive and Liver Diseases, Cedars-Sinai Medical Center, Los Angeles, CA.
Naim AlkhouriArizona Liver Health, Chandler, AZ.
Samantha M NoreenResearch Department, United Network for Organ Sharing, Richmond, VA.
Alice E TollResearch Department, United Network for Organ Sharing, Richmond, VA.
Tsuyoshi TodoDepartment of Surgery, Comprehensive Transplant Center, Cedars-Sinai Medical Center, Los Angeles, CA.
Walid AyoubDivision of Digestive and Liver Diseases, Cedars-Sinai Medical Center, Los Angeles, CA.
Alexander KuoDivision of Digestive and Liver Diseases, Cedars-Sinai Medical Center, Los Angeles, CA.
Georgios VoidonikolasDepartment of Surgery, Comprehensive Transplant Center, Cedars-Sinai Medical Center, Los Angeles, CA.
Honore G KotlerDepartment of Surgery, Comprehensive Transplant Center, Cedars-Sinai Medical Center, Los Angeles, CA.
Michalyn D PelphreyDepartment of Medicine, Comprehensive Transplant Center, Cedars-Sinai Medical Center, Los Angeles, CA.
Brenda J DurandDepartment of Medicine, Comprehensive Transplant Center, Cedars-Sinai Medical Center, Los Angeles, CA.
Kambiz KosariDepartment of Surgery, Comprehensive Transplant Center, Cedars-Sinai Medical Center, Los Angeles, CA.
Todd V BrennanDepartment of Surgery, Comprehensive Transplant Center, Cedars-Sinai Medical Center, Los Angeles, CA.
Irene KimDepartment of Surgery, Comprehensive Transplant Center, Cedars-Sinai Medical Center, Los Angeles, CA.
Andrew S KleinDepartment of Surgery, Comprehensive Transplant Center, Cedars-Sinai Medical Center, Los Angeles, CA.
Ekihiro SekiDivision of Digestive and Liver Diseases, Cedars-Sinai Medical Center, Los Angeles, CA.
Nicholas N NissenDepartment of Surgery, Comprehensive Transplant Center, Cedars-Sinai Medical Center, Los Angeles, CA.
Shelly C LuDivision of Digestive and Liver Diseases, Cedars-Sinai Medical Center, Los Angeles, CA.
Vinay SundaramDivision of Digestive and Liver Diseases, Cedars-Sinai Medical Center, Los Angeles, CA.
Mazen NoureddinDivision of Digestive and Liver Diseases, Cedars-Sinai Medical Center, Los Angeles, CA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundChanging opinions on the alcohol abstinence requirement have led to increased liver transplantation (LT) for alcoholic hepatitis (AH). We aimed to determine the trend in LT for AH in the United States and overall and graft survival rates.

methodsAdult liver-alone and liver-kidney registrations added to the Organ Procurement and Transplantation Network waiting list between 2004 and 2018 were divided into 3 periods (2004-2009, 2010-2013, 2014-2018). Kaplan-Meier survival models illustrated patient and graft survival.

resultsBetween 2004 and 2018, 529 AH patients were registered for and 254 received LT. By periods, 116, 73, and 340 patients were registered for and 49, 17, and 188 patients received LT, respectively, indicating a increase in LT for AH from 2014 to 2018. Yearly registrants from 2014 to 2018 were 32, 47, 51, 70, and 140, and recipients were 16, 24, 24, 38, and 88, respectively, indicating increases of 338% and 450% in registrants and recipients, respectively, since 2014. AH patients had the highest 1- and 3-year posttransplant survival (93.2% and 87.3%, respectively) and graft survival (90.4% and 84.8%, respectively) comparing to other LT recipients.

conclusionsLT for AH in the United States is at an all-time high with an increased overall patient and graft survival.

Identifiers

PMID33134488
PMCPMC7546885

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