ArticleJournal of biomedical physics & engineering2020
Why Do Some Reports Claim that the Number of COVID-19 Hospitalized Smokers is Smaller than Expected?
Article in Journal of biomedical physics & engineering, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
4 citing papers in PubMed, 5 citations in OpenAlex.
- Addressing cigarette smoking cessation treatment challenges during the COVID-19 pandemic with social media.Journal of substance abuse treatment · 2021Review
- Prolactin and susceptibility to COVID-19 infection.Medical hypotheses · 2021Article
- Questioning the sex-specific differences in the association of smoking on the survival rate of hospitalized COVID-19 patients.PloS one · 2021Article
- Revisiting the Paradox of Smoking: Radioactivity in Tobacco Smoke or Suppressing the SARS-CoV-2 Receptor, Angiotensin-Converting Enzyme 2, via Aryl-Hydrocarbon Receptor Signal?Dose-response : a publication of International Hormesis SocietyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Researchers believe that smoking might increase the severity of infections caused by SARS-CoV-2 by altering the viability and integrity of the BBB, while promoting the expression of ACE2 in endothelial cells, glia, and neurons. Moreover, as smoking increases the blood circulatory level of VWF and decreases the levels of thrombomodulin, it can lead to dysregulated blood homeostasis and hence, increased risk of thrombosis which significantly increases the risk of stroke and cardiovascular disorders. However, despite current controversies and remarkable study limitations, a recent systematic review and meta-analysis claims that the findings of 18 recent COVID-19 clinical and epidemiological studies show that smokers were statistically less likely to be hospitalized. The authors state that their observations might be due to the effects of nicotine. We believe that the lower number of hospitalized smokers than expected, if confirmed by further studies, can be due to the higher concentration of deposited energy of alpha particles emitted from radionuclides such as Po-210 in cigarette tobacco. The anti-inflammatory effects of localized radiation energy deposition of alpha particles as well as the effect of low doses of radiation on reducing the risk of thrombosis, are possibly involved in the lower number of hospitalized smokers than expected.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.