ArticleJournal of biomedical physics & engineering2020
Proton Magnetic Resonance Spectroscopy to Detect Correlations between Clinical Symptoms and Brain Metabolite Levels in Patients with Tension-type Headache.
Article in Journal of biomedical physics & engineering, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Altered hypothalamic metabolism in chronic cluster headache patients measured withThe journal of headache and pain · 2026Article
- Bidirectional Mendelian Randomization Analysis of 338 Cerebrospinal-Fluid Metabolites and Cluster-Headache Risk.Journal of pain research · 2026Article
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Authors and funding
4 authors.
Funding
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Abstract
backgroundProton magnetic resonance spectroscopy (
objectiveThis study aims to identify correlations between clinical symptoms in patients with tension-type headache (TTH) and concentrations of brain metabolites. MATERIAL AND
methodsIn this observational study, twenty-four patients (4 men and 20 women) with chronic TTH were included. To evaluate their clinical symptoms, the number of trigger points, headache frequency and headache intensity were recorded. The levels of anxiety and depression were recorded with the Beck Anxiety Inventory (BAI) and Beck Depression Inventory II (BDI- II). Concentrations of brain metabolites were determined in the anterior cingulate cortex, thalamus and primary somatosensory cortex of left hemisphere with
resultsThere was a negative correlation between trigger point count and choline/creatine (Cho/Cr) ratio in the primary somatosensory cortex [r= -0.509, n= 24,
conclusionPatients with more trigger points had a lower Cho/Cr ratio, which may indicate alterations in brain metabolic activity.
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