Evidence map›Paper›PMID 33134000›Full record

ArticleBeilstein journal of nanotechnology2020

Electrokinetic characterization of synthetic protein nanoparticles.

Daniel F Quevedo, Cody J Lentz, Adriana Coll de Peña, Yazmin Hernandez, Nahal Habibi, Rikako Miki, Joerg Lahann, Blanca H Lapizco-Encinas

Open access · diamondAbstract read
In one paragraph

Article in Beilstein journal of nanotechnology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.0field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
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  4. Protein Nanoparticles: Uniting the Power of Proteins with Engineering Design Approaches.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022
    Review
  5. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Daniel F QuevedoBiointerfaces Institute, University of Michigan - Ann Arbor, Ann Arbor MI, USA.ORCID https://orcid.org/0000-0001-5892-364X
Cody J LentzMicroscale Bioseparations Laboratory and Biomedical Engineering Department, Rochester Institute of Technology, Rochester NY, USA.
Adriana Coll de PeñaMicroscale Bioseparations Laboratory and Biomedical Engineering Department, Rochester Institute of Technology, Rochester NY, USA.ORCID https://orcid.org/0000-0002-5419-4539
Yazmin HernandezBiointerfaces Institute, University of Michigan - Ann Arbor, Ann Arbor MI, USA.ORCID https://orcid.org/0000-0003-3802-246X
Nahal HabibiBiointerfaces Institute, University of Michigan - Ann Arbor, Ann Arbor MI, USA.ORCID https://orcid.org/0000-0001-7736-0168
Rikako MikiBiointerfaces Institute, University of Michigan - Ann Arbor, Ann Arbor MI, USA.
Joerg LahannBiointerfaces Institute, University of Michigan - Ann Arbor, Ann Arbor MI, USA.ORCID https://orcid.org/0000-0002-3334-2053
Blanca H Lapizco-EncinasMicroscale Bioseparations Laboratory and Biomedical Engineering Department, Rochester Institute of Technology, Rochester NY, USA.ORCID https://orcid.org/0000-0001-6283-8210
University of Michigan · USRochester Institute of Technology · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The application of nanoparticle in medicine is promising for the treatment of a wide variety of diseases. However, the slow progress in the field has resulted in relatively few therapies being translated into the clinic. Anisotropic synthetic protein nanoparticles (ASPNPs) show potential as a next-generation drug-delivery technology, due to their biocompatibility, biodegradability, and functionality. Even though ASPNPs have the potential to be used in a variety of applications, such as in the treatment of glioblastoma, there is currently no high-throughput technology for the processing of these particles. Insulator-based electrokinetics employ microfluidics devices that rely on electrokinetic principles to manipulate micro- and nanoparticles. These miniaturized devices can selectively trap and enrich nanoparticles based on their material characteristics, and subsequently release them, which allows for particle sorting and processing. In this study, we use insulator-based electrokinetic (EK) microdevices to characterize ASPNPs. We found that anisotropy strongly influences electrokinetic particle behavior by comparing compositionally identical anisotropic and non-anisotropic SPNPs. Additionally, we were able to estimate the empirical electrokinetic equilibrium parameter (e

Indexed as

anisotropybicompartmental particlesdielectrophoresiselectrokineticselectro-osmosiselectrophoresismicrofluidicsprotein nanoparticles

Identifiers

PMID33134000
PMCPMC7590587
OpenAlexW3092814197

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.