Evidence map›Paper›PMID 33133767›Full record

ArticleTremor and other hyperkinetic movements (New York, N.Y.)2020

The Impact of Compulsivity and Impulsivity in Cerebellar Ataxia: A Case Series.

Nadia Amokrane, Chi-Ying R Lin, Natasha A Desai, Sheng-Han Kuo

Open access · goldAbstract readCase Reports
In one paragraph

Article in Tremor and other hyperkinetic movements (New York, N.Y.), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
0.7field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.

  1. Pooled it
  2. Repeated transcranial magnetic stimulation on the bilateral cerebellum to improve symptoms of ataxia with multiple system atrophy: a prospective, randomized, sham-controlled pilot study.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025
    Trial
  3. Impulsivity in cerebellar ataxia: an online, multidimensional assessment.Journal of neural transmission (Vienna, Austria : 1996) · 2026
    Article
  4. Suicidal Ideation in Spinocerebellar Ataxia.The Journal of neuropsychiatry and clinical neurosciences · 2026
    Article
  5. Consensus Paper: Cerebellum and Reward.Cerebellum (London, England) · 2024
    Review
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Cerebellar impulsivity-compulsivity assessment scale.Annals of clinical and translational neurology · 2023
    Article
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Nadia AmokraneDepartment of Neurology, Columbia University Medical Center, New York, NY, US.ORCID 0000-0002-5460-0234
Chi-Ying R LinDepartment of Neurology, Columbia University Medical Center, New York, NY, US.ORCID 0000-0002-9607-974X
Natasha A DesaiDepartment of Neurology, Columbia University Medical Center, New York, NY, US.
Sheng-Han KuoDepartment of Neurology, Columbia University Medical Center, New York, NY, US.ORCID 0000-0002-9412-931X
Columbia University Irving Medical Center · US

Funding

Targeting Cerebellar Excitatory Synapses for Tremor ProgressionR01NS118179 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI KUO, SHENG-HAN · 2020 to 2024
$2.2M
Cerebellar Circuitry in the Pathophysiology of TremorR01NS104423 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI KUO, SHENG-HAN · 2018 to 2022
$2.0M
Dietary Contribution in Cerebellar AtaxiaR03NS114871 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI KUO, SHENG-HAN · 2019 to 2020
$162k
NINDS NIH HHS R01 NS104423NINDS NIH HHS R01 NS118179NINDS NIH HHS R03 NS114871
6 · The paper itself

Abstract

Background: The cerebellum has recently been identified to have a key role in reward processing, and individuals with ataxia have been found to be more impulsive and compulsive as part of cerebellum-related cognitive and behavioral disturbances. Case Report: We reported five individuals with cerebellar ataxia who demonstrate impulsive and compulsive behaviors, including hobbyism, gambling, and compulsive medication use, to illustrate that these symptoms can be highly disabling. Discussion: These five cases provide examples of behavioral symptoms in cerebellar ataxia. Further investigations of the pathomechanism of these symptoms will advance our understanding of the cerebellum in cognition and behavior.

Indexed as

Impulsive BehaviorAdultCompulsive BehaviorCompulsive ExerciseFemaleGamblingHoardingHumansMaleMiddle AgedMultiple System AtrophySpinocerebellar AtaxiasVideo Gamescerebellar ataxiacerebellumcompulsivityimpulsivityreward

Identifiers

PMID33133767
PMCPMC7583703
OpenAlexW3093110856

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.