Evidence map›Paper›PMID 33133729›Full record

ArticleJournal of pharmaceutical analysis2020

Strategies for PET imaging of the receptor for advanced glycation endproducts (RAGE).

Lindsey R Drake, Allen F Brooks, Jenelle Stauff, Phillip S Sherman, Janna Arteaga, Robert A Koeppe, Aimee Reed, Timothy J Montavon, Marc B Skaddan, Peter J H Scott

Open access · goldAbstract read
In one paragraph

Article in Journal of pharmaceutical analysis, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.6field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 17 citations in OpenAlex.

  1. Review
  2. Review
  3. In vivo methods for imaging blood-brain barrier function and dysfunction.European journal of nuclear medicine and molecular imaging · 2023
    Review
  4. Article
  5. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Lindsey R DrakeDepartment of Radiology, University of Michigan, Ann Arbor, MI, 48109, USA.
Allen F BrooksDepartment of Radiology, University of Michigan, Ann Arbor, MI, 48109, USA.
Jenelle StauffDepartment of Radiology, University of Michigan, Ann Arbor, MI, 48109, USA.
Phillip S ShermanDepartment of Radiology, University of Michigan, Ann Arbor, MI, 48109, USA.
Janna ArteagaDepartment of Radiology, University of Michigan, Ann Arbor, MI, 48109, USA.
Robert A KoeppeDepartment of Radiology, University of Michigan, Ann Arbor, MI, 48109, USA.
Aimee ReedAbbVie Process Chemistry, North Chicago, IL, 60064, USA.
Timothy J MontavonAbbVie Centralized Medicinal Chemistry, North Chicago, IL, 60064, USA.
Marc B SkaddanAbbVie Translational Imaging, North Chicago, IL, 60064, USA.
Peter J H ScottDepartment of Radiology, University of Michigan, Ann Arbor, MI, 48109, USA.
University of Michigan · USAbbVie (United States) · US

Funding

INTERDEPARTMENTAL TRAINING IN PHARMACOLOGICAL SCIENCEST32GM007767 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ISOM, LORI L. · 1985 to 2019
$10.2M
NIGMS NIH HHS T32 GM007767
6 · The paper itself

Abstract

The implication of the receptor for advanced glycation end-products (RAGE) in numerous diseases and neurodegenerative disorders makes it interesting both as a therapeutic target and as an inflammatory biomarker. In the context of investigating RAGE as a biomarker, there is interest in developing radiotracers that will enable quantification of RAGE using positron emission tomography (PET) imaging. We have synthesized potential small molecule radiotracers for both the intracellular ([

Indexed as

NeuroimagingNeuroinflammationPositron emission tomographyRadiochemistryRAGE

Identifiers

PMID33133729
PMCPMC7591811
OpenAlexW3047122727

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.