ArticleFood science & nutrition2020
Beneficial health effects of Menaquinone-7 on body composition, glycemic indices, lipid profile, and endocrine markers in polycystic ovary syndrome patients.
Article in Food science & nutrition, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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The trial behind it
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Who cites it
21 citing papers in PubMed, 35 citations in OpenAlex.
- Vitamins K2 and D3 Improve Long COVID, Fungal Translocation, and Inflammation: Randomized Controlled Trial.Nutrients · 2025Trial
- Effect of vitamin K2 administration on depression status in patients with polycystic ovary syndrome: a randomized clinical trial.BMC women's health · 2022Trial
- Hormonal Imbalance and Gut Dysbiosis: Emerging Perspectives in Women's Health.Probiotics and antimicrobial proteins · 2026Review
- Sex-Specific Effects of Menaquinone-7 (MK-7) Supplementation on Body Composition and Adiposity Markers.Nutrients · 2026Article
- Vitamin K as an Endocrine Modulator: Mechanistic Links to Glucose Metabolism and Beyond.Nutrients · 2026Review
- Estropausal gut microbiota transplant improves measures of ovarian function in adult mice.Nature aging · 2026Article
- Vitamin K and muscle health: mechanisms and clinical perspectives in sarcopenia and beyond: narrative review.Frontiers in nutrition · 2026Review
- Nutrients and bioactive compounds in polycystic ovary syndrome: updated insights into effects and underlying mechanisms.Frontiers in nutrition · 2026Review
- Vitamin K2 Alleviates Insulin Resistance Associated Skeletal Muscle Atrophy via the AKT/mTOR Signalling Pathway.Journal of cachexia, sarcopenia and muscle · 2025Article
- Are there Effective Vegan-Friendly Supplements for Optimizing Health and Sports Performance? a Narrative Review.Current nutrition reports · 2025Review
- The Impact of Amine-Functionalised Iron Oxide Nanoparticles on the Menaquinone-7 Isomer Profile and Production of the Bioactive Isomer.Molecular biotechnology · 2024Article
- Vitamin K2 protects mice against non-alcoholic fatty liver disease induced by high-fat diet.Scientific reports · 2024Article
- Revisiting the interconnection between lipids and vitamin K metabolism: insights from recent research and potential therapeutic implications: a review.Nutrition & metabolism · 2024Review
- The role of vitamin K2 in cognitive impairment: linking vascular health to brain health.Frontiers in aging neuroscience · 2024Review
- The Effect of Iron Oxide Nanoparticles on the Menaquinone-7 Isomer Composition and Synthesis of the Biologically Significant All-Nanomaterials (Basel, Switzerland) · 2023Article
- Lifestyle management in polycystic ovary syndrome - beyond diet and physical activity.BMC endocrine disorders · 2023Review
- Nutritional Supplements and Complementary Therapies in Polycystic Ovary Syndrome.Advances in nutrition (Bethesda, Md.) · 2022Review
- Optimisation of the fermentation media to enhance the production of the bioactive isomer of vitamin menaquinone-7.Bioprocess and biosystems engineering · 2022Article
- Effects of Alkali Stress on the Growth and Menaquinone-7 Metabolism ofFrontiers in microbiology · 2022Article
- The Role of Vitamin K in Humans: Implication in Aging and Age-Associated Diseases.Antioxidants (Basel, Switzerland) · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe aim of this study was to investigate the effect of oral vitamin K2 (Menaquinone-7 [MK-7]) on clinical and biochemical parameters in polycystic ovary syndrome (PCOS) patients.
methodsIn this randomized, double-blind, placebo-controlled clinical trial, 84 PCOS patients were randomly assigned into the treatment (90 µg Menaquinone-7 daily for 8 weeks) and placebo groups. Insulin resistance, lipid profile, endocrine biomarkers, and body composition of the participants were measured before and after the intervention. This study was performed in Ghadir Mother & Child Hospital affiliated to Shiraz University of Medical Sciences, Shiraz, Iran.
resultsMenaquinone-7 supplementation, when compared to placebo, significantly decreased serum fasting insulin (
conclusionsThis study highlights the beneficial effects of MK-7 on insulin resistance, fat mass, skeletal muscle, and serum levels of triglyceride, DHT, and SHBG in PCOS patients. Therefore, it seems that MK-7 supplementation might be an appropriate additive treatment for PCOS patients.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.