ArticleWorld journal of gastrointestinal oncology2020
Prognostic factors and therapeutic effects of different treatment modalities for colorectal cancer liver metastases.
Article in World journal of gastrointestinal oncology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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7 citing papers in PubMed, 11 citations in OpenAlex.
- TCF21-WNT5A axis drives metastasis of colorectal cancer via stromal-tumor cell communication.Journal of translational medicine · 2026Article
- Construction and interpretation of weight-balanced enhanced machine learning models for predicting liver metastasis risk in colorectal cancer patients.Discover oncology · 2025Article
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- Predicting early recurrence of colorectal cancer liver metastases: an integrative approach using radiomics and machine learning.Frontiers in oncology · 2025Article
- Nomograms for predicting overall survival in colorectal cancer patients with metastasis to the liver, lung, bone, and brain.Cancer causes & control : CCC · 2023Article
- Article
- The predictive value of galectin-1 and vascular mimicry in the prognostic evaluation of patients with rectal cancer.Translational cancer research · 2021Article
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10 authors at 1 institution in 1 country.
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Abstract
backgroundColorectal cancer (CRC) is one of the most common malignant tumors in China, and the liver is the most common metastatic site in patients with advanced CRC. Hepatectomy is the gold standard treatment for colorectal liver metastases. For patients who cannot undergo radical resection of liver metastases for various reasons, ablation therapy, interventional therapy, and systemic chemotherapy can be used to improve their quality of life and prolong their survival time.
aimTo explore the prognostic factors and treatments of liver metastases of CRC.
methodsA retrospective analysis was conducted on 87 patients with liver metastases from CRC treated at the Liaoning Cancer Hospital and Institute between January 2005 and March 2011. According to different treatments, the patients were divided into the following four groups: Surgical resection group (36 patients); ablation group (23 patients); intervention group (15 patients); and drug group (13 patients). The clinicopathological data and postoperative survival of the four groups were analyzed. The Kaplan-Meier method was used for survival analysis, and the Cox proportional hazards regression model was used for multivariate analysis.
resultsThe median survival time of the 87 patients was 38.747 ± 3.062 mo, and the 1- and 3-year survival rates were 87.5% and 53.1%, respectively. The Cox proportional hazards model showed that the following factors were independent factors affecting prognosis: The degree of tumor differentiation, the number of metastases, the size of metastases, and whether the metastases are close to great vessels. The results of treatment factor analysis showed that the effect of surgical treatment was better than that of drugs, intervention, or ablation alone, and the median survival time was 48.83 ± 4.36 mo. The drug group had the worst prognosis, with a median survival time of only 13.5 ± 0.7 mo (
conclusionPatients with a low degree of primary tumor differentiation, multiple liver metastases (number of tumors > 4), and maximum diameter of liver metastases > 5 cm have a poor prognosis. Among drug therapy, intervention, ablation, and surgical treatment options, surgical treatment is the first choice for liver metastases. When liver metastases are close to great vessels, surgical treatment is significantly better than drug therapy, intervention, and ablation alone.
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