ArticleEFSA journal. European Food Safety Authority2020
Assessment of the impact of the IARC Monograph Vol. 121 on the safety of the substance styrene (FCM No 193) for its use in plastic food contact materials.
Article in EFSA journal. European Food Safety Authority, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 37 citations in OpenAlex.
- Polystyrene-degrading bacteria modulate host stress and toxicity responses to microplastic exposure in Caenorhabditis elegans.The ISME journal · 2026Article
- Thermoset Polyester Resin Microplastics: Effects on Enzymatic Biomarkers and Toxicological Endpoint Responses ofToxics · 2025Article
- Development and Characterization of LDPE/EVA Films Incorporating Carvacrol Essential Oil with Antifungal Activity.Foods (Basel, Switzerland) · 2025Article
- Plain Language Summary of the Re-assessment of the risks to public health related to the genotoxicity of styrene present in plastic food contact materials.EFSA journal. European Food Safety Authority · 2025Article
- Re-assessment of the risks to public health related to the genotoxicity of styrene present in plastic food contact materials.EFSA journal. European Food Safety Authority · 2025Article
- Determination of 4-tert-butyl pyrocatechol content in styrene with high accuracy using a chromatographic device under safe conditions: a laboratory study.Scientific reports · 2025Article
- Following the fate of polystyrene micro and nanobeads duringCurrent research in food science · 2025Article
- Essential Oils as Potential Natural Antioxidants, Antimicrobial, and Antifungal Agents in Active Food Packaging.Antibiotics (Basel, Switzerland) · 2024Review
- Microplastics and nanoplastics: Exposure and toxicological effects require important analysis considerations.Heliyon · 2024Review
- Scientific opinion on the renewal of the authorisation of Scansmoke SEF7525 (SF-004) as a smoke flavouring Primary Product.EFSA journal. European Food Safety Authority · 2023Article
- Styrene Monomer Levels in Polystyrene-Packed Dairy Products from the Market versus Simulated Migration Testing.Foods (Basel, Switzerland) · 2023Article
- In vivo mutagenicity assessment of styrene in MutaMouse liver and lung.Genes and environment : the official journal of the Japanese Environmental Mutagen Society · 2023Article
- Analysis of oligomers to assess exposure to microplastics from foods. A perspective.Frontiers in nutrition · 2023Article
- Peer review of the pesticide risk assessment of the active substance fat distillation residues.EFSA journal. European Food Safety Authority · 2023Review
- Safety and efficacy of feed additives consisting of essential oils from the bark and the leaves ofEFSA journal. European Food Safety Authority · 2022Article
- Safety and efficacy of a feed additive consisting of an essential oil fromEFSA journal. European Food Safety Authority · 2022Article
- Peer review of the pesticide risk assessment of the active substance quartz sand.EFSA journal. European Food Safety Authority · 2022Review
- Migration of Styrene in Yogurt and Dairy Products Packaged in Polystyrene: Results from Market Samples.Foods (Basel, Switzerland) · 2022Article
- Peer review of the pesticide risk assessment of the active substance limestone powder (calcium carbonate).EFSA journal. European Food Safety Authority · 2022Review
- Clinical Application of Enteral Nutrition Combined with Microbial Preparation for Intestinal Preparation in Elderly Patients with Colorectal Cancer.Medical science monitor : international medical journal of experimental and clinical research · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
27 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The EFSA Panel on Food Contact Materials, Enzymes and Processing Aids (CEP) was requested by the European Commission to re-evaluate the safety of styrene (FCM No 193) for use in plastic food contact materials (FCM) following the classification by the International Agency for Research on Cancer (IARC) as 'probably carcinogenic to humans'. The IARC Monograph pertains to hazard identification, based on studies on high-dose occupational exposures by inhalation and animal studies, also mainly by inhalation. The Panel considered that the IARC conclusions cannot be directly applied to the evaluation of risks for consumers from the oral exposure to styrene, but also concluded that, based on the data provided in the IARC Monograph and by the industry, a concern for genotoxicity associated with oral exposure to styrene cannot be excluded. The migration of styrene into foods packed in styrenic plastics is below 10 μg/kg for the majority of the foods, but up to 230 μg/kg was reported. Migration tends to be high for contact with fatty foods, and/or with high surface to volume ratios of the FCM. Dietary exposure of the consumers to styrene migrating from styrenic plastics was estimated in the order of 0.1 μg/kg body weight (bw) per day. It is in the same range as exposure from styrene present in foods as such. The dietary exposure (food component plus migration from styrenic plastics) is similar or lower than that by inhalation in the general population. Taking the human exposure data into account, the Panel concluded that a systematic review of genotoxicity and mechanistic data, comparative toxicokinetics and analysis of species differences is required for assessing the safety of styrene for its use in FCM.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.