Evidence map›Paper›PMID 33133130›Full record

ArticleFrontiers in genetics2020

Kernel Fusion Method for Detecting Cancer Subtypes via Selecting Relevant Expression Data.

Shuhao Li, Limin Jiang, Jijun Tang, Nan Gao, Fei Guo

Open access · goldAbstract read
In one paragraph

Article in Frontiers in genetics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 25 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Shuhao LiSchool of Computer Science and Technology, College of Intelligence and Computing, Tianjin University, Tianjin, China.
Limin JiangSchool of Computer Science and Technology, College of Intelligence and Computing, Tianjin University, Tianjin, China.
Jijun TangSchool of Computer Science and Technology, College of Intelligence and Computing, Tianjin University, Tianjin, China.
Nan GaoSchool of Computer Science and Technology, Zhejiang University of Technology, Hangzhou, China.
Fei GuoSchool of Computer Science and Technology, College of Intelligence and Computing, Tianjin University, Tianjin, China.
University of South Carolina · USZhejiang University of Technology · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Recently, cancer has been characterized as a heterogeneous disease composed of many different subtypes. Early diagnosis of cancer subtypes is an important study of cancer research, which can be of tremendous help to patients after treatment. In this paper, we first extract a novel dataset, which contains gene expression, miRNA expression, and isoform expression of five cancers from The Cancer Genome Atlas (TCGA). Next, to avoid the effect of noise existing in 60, 483 genes, we select a small number of genes by using LASSO that employs gene expression and survival time of patients. Then, we construct one similarity kernel for each expression data by using Chebyshev distance. And also, We used SKF to fused the three similarity matrix composed of gene, Iso, and miRNA, and finally clustered the fused similarity matrix with spectral clustering. In the experimental results, our method has better

Indexed as

cancer subtypegene expressionisform levelLASSOmiRNA expressionsimilarity Kernel fusion

Identifiers

PMID33133130
PMCPMC7511763
OpenAlexW3085331870

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.