Evidence map›Paper›PMID 33133088›Full record

ArticleFrontiers in immunology2020

Replacement of TCR Dβ With Immunoglobulin D

Michael Levinson, Mohamed Khass, Peter D Burrows, Harry W Schroeder

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.1field-weighted citation impact, top 57% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Michael LevinsonDivision of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, United States.
Mohamed KhassDivision of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, United States.
Peter D BurrowsDepartment of Microbiology, University of Alabama at Birmingham, Birmingham, AL, United States.
Harry W SchroederDivision of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, United States.
University of Alabama at Birmingham · USNational Water Research Center · EG

Funding

IMMUNOLOGIC DISEASES AND BASIC IMMUNOLOGYT32AI007051 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Laurie Ellen Harrington · 1985 to 2026
$13.1M
HLA Region and KIR Genomics in Common Variable Immune DeficiencyU01AI090902 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI SCHROEDER, HARRY WILLIAM · 2010 to 2014
$2.9M
Role of VpreB in immunoglobulin antigen binding site selectionR21AI134027 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI SCHROEDER, HARRY WILLIAM · 2018 to 2019
$408k
The pre-BCR CDR-H3 sensing site and H chain selectionR21AI117703 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI SCHROEDER, HARRY WILLIAM · 2015 to 2016
$404k
NIAID NIH HHS R21 AI117703NIAID NIH HHS R21 AI134027NIAID NIH HHS T32 AI007051NIAID NIH HHS U01 AI090902
6 · The paper itself

Abstract

Enrichment for tyrosine in immunoglobulin CDR-H3 is due in large part to natural selection of germline immunoglobulin D

Indexed as

Complementarity Determining RegionsGenes, Immunoglobulin Heavy ChainGenes, T-Cell Receptor betaAnimalsImmunizationImmunodominant EpitopesImmunoglobulin Heavy ChainsLymphocyte ActivationMice, Inbred C57BLMice, KnockoutOvalbuminPhenotypeReceptors, Antigen, T-Cell, alpha-betaThymocytesT-LymphocytesTyrosineComplementarity Determining RegionsImmunodominant EpitopesImmunoglobulin Heavy ChainsOvalbuminReceptors, Antigen, T-Cell, alpha-betaTyrosineCDR-B3Db1germline selectionimmunoglobulin DSP2.3TCRB diversity

Identifiers

PMID33133088
PMCPMC7550431
OpenAlexW3091066476

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.