Evidence map›Paper›PMID 33133085›Full record

ArticleFrontiers in immunology2020

Flow Cytometry-Based Protocols for the Analysis of Human Plasma Cell Differentiation.

Sharesta Khoenkhoen, Monika Ádori, Gabriel K Pedersen, Gunilla B Karlsson Hedestam

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 16 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Sharesta KhoenkhoenDepartment of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden.
Monika ÁdoriDepartment of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden.
Gabriel K PedersenDepartment of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden.
Gunilla B Karlsson HedestamDepartment of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden.
Karolinska Institutet · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Humoral immunity is established after differentiation of antigen-specific B cells into plasma cells (PCs) that produce antibodies of relevant specificities. Defects in the development, activation, or differentiation of B cells severely compromises the immune response. Primary immunodeficiencies are often characterized by hypogammaglobulinemia and the inability to mount effective antigen-specific antibody responses, resulting in increased susceptibility to infections. After IgA deficiency, which is most often asymptomatic, common variable immunodeficiency (CVID) is the most prevalent symptomatic primary immunodeficiency, but in most cases the underlying genetic causes are unknown or their roles in disease pathogenesis are poorly understood. In this study, we developed a protocol for

Indexed as

ADP-ribosyl Cyclase 1Antibody FormationB-LymphocytesCell DifferentiationCell ProliferationCells, CulturedCommon Variable ImmunodeficiencyFlow CytometryHumansImmunophenotypingInterferon Regulatory Factor-4Interferon Regulatory FactorsLymphocyte ActivationPAX5 Transcription FactorPlasma CellsPositive Regulatory Domain I-Binding Factor 1ADP-ribosyl Cyclase 1Interferon Regulatory Factor-4Interferon Regulatory FactorsPAX5 protein, humanPAX5 Transcription FactorPositive Regulatory Domain I-Binding Factor 1PRDM1 protein, humanB cell proliferationBlimp-1/PRDM1common variable immunodeficiencyCVIDIRF4Pax5plasma cell differentiation

Identifiers

PMID33133085
PMCPMC7550473
OpenAlexW3090908966

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.