Evidence map›Paper›PMID 33133081›Full record

ArticleFrontiers in immunology2020

Downregulation of p53 by Insufficient CTCF in CD4

Juan Hua, Yan Chen, Bin Fu, Xu Chen, Xue-Jun Xu, Shuang-Hui Yang, Cong Chen, Ya-Jing Xu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.4field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. The absence of AhR in CD4Clinical epigenetics · 2022
    Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Juan HuaDepartment of Hematology, Xiangya Hospital, Central South University, Changsha, China.
Yan ChenDepartment of Hematology, Xiangya Hospital, Central South University, Changsha, China.
Bin FuDepartment of Hematology, Xiangya Hospital, Central South University, Changsha, China.
Xu ChenDepartment of Hematology, Xiangya Hospital, Central South University, Changsha, China.
Xue-Jun XuDepartment of Hematology, Xiangya Hospital, Central South University, Changsha, China.
Shuang-Hui YangDepartment of Hematology, Xiangya Hospital, Central South University, Changsha, China.
Cong ChenDepartment of Hematology, Xiangya Hospital, Central South University, Changsha, China.
Ya-Jing XuDepartment of Hematology, Xiangya Hospital, Central South University, Changsha, China.
Xiangya Hospital Central South University · CNCentral South University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Recent evidence indicates that p53 plays a protective role against various systemic autoimmune diseases by suppressing pro-inflammatory cytokine production and reducing the number of pathogenic T cells. However, whether abnormal p53 expression participates in the development of acute graft-versus-host disease (aGVHD) remains unclear. In this study, we demonstrated that p53 was downregulated in CD4

Indexed as

AdultCCCTC-Binding FactorCD4-Positive T-LymphocytesDown-RegulationFemaleGraft vs Host DiseaseHumansMaleTumor Suppressor Protein p53CCCTC-Binding FactorCTCF protein, humanTumor Suppressor Protein p53aGVHDCD4+ T cellCTCFP300p53

Identifiers

PMID33133081
PMCPMC7550539
OpenAlexW3090964201

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.