Evidence map›Paper›PMID 33133076›Full record

ArticleFrontiers in immunology2020

Chimeric Virus-Like Particles and Capsomeres Induce Similar CD8

David J Pattinson, Simon H Apte, Nani Wibowo, Tania Rivera-Hernandez, Penny L Groves, Anton P J Middelberg, Denise L Doolan

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.3field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Virus-like Particles: Fundamentals and Biomedical Applications.International journal of molecular sciences · 2022
    Review
  6. Adenovirus-based vaccines-a platform for pandemic preparedness against emerging viral pathogens.Molecular therapy : the journal of the American Society of Gene Therapy · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

David J PattinsonInfectious Diseases Programme, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.
Simon H ApteInfectious Diseases Programme, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.
Nani WibowoAustralian Institute for Bioengineering and Nanotechnology, University of Queensland, Brisbane, QLD, Australia.
Tania Rivera-HernandezAustralian Institute for Bioengineering and Nanotechnology, University of Queensland, Brisbane, QLD, Australia.
Penny L GrovesInfectious Diseases Programme, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.
Anton P J MiddelbergAustralian Institute for Bioengineering and Nanotechnology, University of Queensland, Brisbane, QLD, Australia.
Denise L DoolanInfectious Diseases Programme, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.
University of Queensland · AUQIMR Berghofer Medical Research Institute · AUAustralian Institute of Tropical Health and Medicine · AUJames Cook University · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Despite extensive research, the development of an effective malaria vaccine remains elusive. The induction of robust and sustained T cell and antibody response by vaccination is an urgent unmet need. Chimeric virus-like particles (VLPs) are a promising vaccine platform. VLPs are composed of multiple subunit capsomeres which can be rapidly produced in a cost-effective manner, but the ability of capsomeres to induce antigen-specific cellular immune responses has not been thoroughly investigated. Accordingly, we have compared chimeric VLPs and their sub-unit capsomeres for capacity to induce CD8

Indexed as

AnimalsAntibodies, ViralCapsid ProteinsCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesEpitopes, B-LymphocyteEpitopes, T-LymphocyteFemaleImmunity, CellularImmunizationInterferon-gammaMalaria VaccinesMiceMice, Inbred BALB CMutagenesis, InsertionalPlasmodium yoeliiAntibodies, ViralCapsid ProteinsEpitopes, B-LymphocyteEpitopes, T-LymphocyteIFNG protein, mouseInterferon-gammaMalaria VaccinesVaccines, Virus-Like ParticleVP1 protein, polyomaviruscapsomerechimericmalariamurine polyomavirusPlasmodium yoeliiT cellsvaccinevirus-like particle

Identifiers

PMID33133076
PMCPMC7550421
OpenAlexW3090303973

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.