ArticleFrontiers in synaptic neuroscience2020
The Synapse Diversity Dilemma: Molecular Heterogeneity Confounds Studies of Synapse Function.
Article in Frontiers in synaptic neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 41 citations in OpenAlex.
- Synaptopathy in the TDP-43ΔNLS Mouse Model of Sporadic Amyotrophic Lateral Sclerosis.The European journal of neuroscience · 2025Article
- Input-Specific Localization of NMDA Receptor GluN2 Subunits in Thalamocortical Neurons.Journal of neurochemistry · 2025Article
- Input-specific localization of NMDA receptor GluN2 subunits in thalamocortical neurons.bioRxiv : the preprint server for biology · 2024Article
- Neuron type-specific proteomics reveals distinct Shank3 proteoforms in iSPNs and dSPNs lead to striatal synaptopathy in Shank3BMolecular psychiatry · 2024Article
- Adaptation of Magnified Analysis of the Proteome for Excitatory Synaptic Proteins in Varied Samples and Evaluation of Cell Type-Specific Distributions.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Article
- Protein 4.1N Plays a Cell Type-Specific Role in Hippocampal Glutamatergic Synapse Regulation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Multi-synaptic boutons are a feature of CA1 hippocampal connections in the stratum oriens.Cell reports · 2023Article
- Transcriptional diversity in specific synaptic gene sets discriminates cortical neuronal identity.Biology direct · 2023Article
- Denervated mouse CA1 pyramidal neurons express homeostatic synaptic plasticity following entorhinal cortex lesion.Frontiers in molecular neuroscience · 2023Article
- Synapse-specific diversity of distinct postsynaptic GluN2 subtypes defines transmission strength in spinal lamina I.Frontiers in synaptic neuroscience · 2023Article
- Introduction: What Are Dendritic Spines?Advances in neurobiology · 2023Article
- Morphological Features of Human Dendritic Spines.Advances in neurobiology · 2023Review
- Combined DiI and Antibody Labeling Reveals Complex Dysgenesis of Hippocampal Dendritic Spines in a Mouse Model of Fragile X Syndrome.Biomedicines · 2022Article
- Keeping synapses in shape: degradation pathways in the healthy and aging brain.Neuronal signaling · 2022Review
- Selective vulnerability of tripartite synapses in amyotrophic lateral sclerosis.Acta neuropathologica · 2022Article
- Alternative neural systems: What is a neuron? (Ctenophores, sponges and placozoans).Frontiers in cell and developmental biology · 2022Article
- Editorial: From Whole-Cell to Single Synapse Engrams - Breaking the Code for Memory Formation, Storage and Recall.Frontiers in molecular neuroscience · 2022Article
- Unraveling Brain Microcircuits, Dendritic Spines, and Synaptic Processing Using Multiple Complementary Approaches.Frontiers in physiology · 2022Article
- Diversity of synaptic protein complexes as a function of the abundance of their constituent proteins: A modeling approach.PLoS computational biology · 2022Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 2 countries.
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Abstract
Recent studies have shown an unexpectedly high degree of synapse diversity arising from molecular and morphological differences among individual synapses. Diverse synapse types are spatially distributed within individual dendrites, between different neurons, and across and between brain regions, producing the synaptome architecture of the brain. The spatial organization of synapse heterogeneity is important because the physiological activation of heterogeneous excitatory synapses produces a non-uniform spatial output of synaptic potentials, which confounds the interpretation of measurements obtained from population-averaging electrodes, optrodes and biochemical methods that lack single-synapse resolution. Population-averaging measurements cannot distinguish between changes in the composition of populations of synapses and changing synaptic physiology. Here we consider the implications of synapse diversity and its organization into synaptome architecture for studies of synapse physiology, plasticity, development and behavior, and for the interpretation of phenotypes arising from pharmacological and genetic perturbations. We conclude that prevailing models based on population-averaging measurements need reconsideration and that single-synapse resolution physiological recording methods are required to confirm or refute the major synaptic models of behavior.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.