Evidence map›Paper›PMID 33132888›Full record

ArticleFrontiers in human neuroscience2020

Contraction Phase and Force Differentially Change Motor Evoked Potential Recruitment Slope and Interhemispheric Inhibition in Young Versus Old.

Elsa Ermer, Stacey Harcum, Jaime Lush, Laurence S Magder, Jill Whitall, George F Wittenberg, Michael A Dimyan

Abstract read
In one paragraph

Article in Frontiers in human neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Elsa ErmerUniversity of Maryland, Baltimore, MD, United States.
Stacey HarcumUniversity of Maryland, Baltimore, MD, United States.
Jaime LushUniversity of Maryland, Baltimore, MD, United States.
Laurence S MagderDepartment of Epidemiology and Public Health, School of Medicine, University of Maryland, Baltimore, Baltimore, MD, United States.
Jill WhitallUniversity of Maryland, Baltimore, MD, United States.
George F WittenbergUniversity of Maryland, Baltimore, MD, United States.
Michael A DimyanUniversity of Maryland, Baltimore, MD, United States.

Funding

University of Maryland Claude D. Pepper Older Americans Independence Center (UM-OAIC)P30AG028747 · NIA · UNIVERSITY OF MARYLAND BALTIMORE · PI Stephen L. Seliger · 2006 to 2026
$28.9M
Modulation of interhemispheric interactions and arm activity after strokeK23NS088107 · NINDS · UNIVERSITY OF MARYLAND BALTIMORE · PI DIMYAN, MICHAEL · 2014 to 2018
$920k
NIA NIH HHS P30 AG028747NINDS NIH HHS K23 NS088107
6 · The paper itself

Abstract

Interhemispheric interactions are important for arm coordination and hemispheric specialization. Unilateral voluntary static contraction is known to increase bilateral corticospinal motor evoked potential (MEP) amplitude. It is unknown how increasing and decreasing contraction affect the opposite limb. Since dynamic muscle contraction is more ecologically relevant to daily activities, we studied MEP recruitment using a novel method and short interval interhemispheric inhibition (IHI) from active to resting hemisphere at 4 phases of contralateral ECR contraction: Rest, Ramp Up [increasing at 25% of maximum voluntary contraction (MVC)], Execution (tonic at 50% MVC), and Ramp Down (relaxation at 25% MVC) in 42 healthy adults. We analyzed the linear portion of resting extensor carpi radialis (ECR) MEP recruitment by stimulating at multiple intensities and comparing slopes, expressed as mV per TMS stimulation level, via linear mixed modeling. In younger participants (age ≤ 30), resting ECR MEP recruitment slopes were significantly and equally larger both at Ramp Up (slope increase = 0.047,

Indexed as

agingcortical dynamicsdisinhibitioninterhemispheric inhibition (IHI)motor evoked potential (MEP) recruitment slope

Identifiers

PMID33132888
PMCPMC7573560

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.