ArticleJournal of Taibah University Medical Sciences2020
Preparing polycaprolactone scaffolds using electrospinning technique for construction of artificial periodontal ligament tissue.
Article in Journal of Taibah University Medical Sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 21 citations in OpenAlex.
- A Systematic Review of Stem Cells in Iraqi Studies.International journal of hematology-oncology and stem cell research · 2026Review
- Evaluation of Random and Aligned Polycaprolactone Nanofibrous Electrospun Scaffold for Human Periodontal Ligament Engineering in Biohybrid Titanium Implants.International journal of dentistry · 2024Article
- The Manufacturing Conditions for the Direct and Reproducible Formation of Electrospun PCL/Gelatine 3D Structures for Tissue Regeneration.Nanomaterials (Basel, Switzerland) · 2023Article
- In Vitro Investigation of Gelatin/Polycaprolactone Nanofibers in Modulating Human Gingival Mesenchymal Stromal Cells.Materials (Basel, Switzerland) · 2023Article
- A review on the recent applications of synthetic biopolymers in 3D printing for biomedical applications.Journal of materials science. Materials in medicine · 2023Review
- Effects of Six Processing Parameters on the Size of PCL Fibers Prepared by Melt Electrospinning Writing.Micromachines · 2023Article
- Papaverine Enhances the Oncolytic Effects of Newcastle Disease Virus on Breast Cancer In Vitro and In Vivo.International journal of microbiology · 2023Article
- Challenges of Periodontal Tissue Engineering: Increasing Biomimicry through 3D Printing and Controlled Dynamic Environment.Nanomaterials (Basel, Switzerland) · 2022Review
- Bio-hybrid dental implants prepared using stem cells with β-TCP-coated titanium and zirconia.Journal of periodontal & implant science · 2022Article
- Biological properties of polycaprolactone and barium titanate composite in biomedical applications.Science progressReview
- Evaluation of bioactivity and biodegradability of a biomimetic soft tissue scaffold for clinical use: AnJournal of Indian Society of PeriodontologyArticle
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThe strategies of tissue-engineering led to the development of living cell-based therapies to repair lost or damaged tissues, including periodontal ligament and to construct biohybrid implant. This work aimed to isolate human periodontal ligament stem cells (hPDLSCs) and implant them on fabricated polycaprolactone (PCL) for the regeneration of natural periodontal ligament (PDL) tissues.
methodshPDLSCs were harvested from extracted human premolars, cultured, and expanded to obtain PDL cells. A PDL-specific marker (periostin) was detected using an immunofluorescent assay. Electrospinning was applied to fabricate PCL at three concentrations (13%, 16%, and 20% weight/volume) in two forms, which were examined through field emission scanning electron microscopy (FESEM). The isolated hPDLSCs were implanted on the fabricated PCL. After 21 days, FESEM was conducted to evaluate the implanted scaffolds, and an MTT assay was performed to characterize the biological response of the PCL scaffold at different cell exposure durations (24, 48, and 72 h).
resultsPeriostin was expressed in the expanded PDL cells, and this result revealed that 20% weight/volume PCL scaffold with a pore size of more than 10 μm was the best. The growth rates of PDLSCs were high. Cytotoxicity test of fabricated PCL scaffold demonstrated no significant change in the cell viability when compared with the negative control and no deteriorating or inhibitory effect on growth after different durations.
conclusionsA cell sheet was successfully formed by using PCL as a scaffold to cover dental implants and promote PDL cell attachment, proliferation, and growth for biohybrid implant construction.
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