Evidence map›Paper›PMID 33132689›Full record

ArticleJournal of porphyrins and phthalocyanines2019

Synthesis and investigation of phthalocyanine-biotin conjugates.

Elizabeth A Okoth, Zehua Zhou, Benson Ongarora, Alyssa Stutes, J Michael Mathis, M Graça H Vicente

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of porphyrins and phthalocyanines, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 58% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Elizabeth A OkothDepartment of Chemistry, Louisiana State University, Baton Rouge, LA 70803, USA.
Zehua ZhouDepartment of Chemistry, Louisiana State University, Baton Rouge, LA 70803, USA.
Benson OngaroraDepartment of Chemistry, Louisiana State University, Baton Rouge, LA 70803, USA.
Alyssa StutesDepartment of Chemistry, Louisiana State University, Baton Rouge, LA 70803, USA.
J Michael MathisDepartment of Comparative Biomedical Sciences, Louisiana State University School of Veterinary Medicine, Baton Rouge Louisiana 70803, USA.
M Graça H VicenteDepartment of Chemistry, Louisiana State University, Baton Rouge, LA 70803, USA.
Louisiana State University · US

Funding

CRC-specific near-IR agents for tumor imagingR01CA179902 · NCI · LOUISIANA STATE UNIV A&M COL BATON ROUGE · PI VICENTE, MARIA DA GRACA HENRIQUES · 2014 to 2017
$1.2M
NCI NIH HHS R01 CA179902
6 · The paper itself

Abstract

An isothiocyanato-functionalized phthalocyanine (Pc) was synthesized in good yield from the corresponding amine-substituted Pc. This Pc reacted with ethanolamine, biotin hydrazine, and biotin diethylamine under mild conditions (room temperature in DMF or DMSO in the presence of TEA) to produce the corresponding thiourea products in 60-75% yields. All Pcs showed intense Q absorptions in DMF around 677 nm, emissions centered at 683 nm, and fluorescence quantum yields in the range 0.18-0.27. The Pcs were phototoxic to human carcinoma HEp2 cells (IC

Indexed as

biotinisothiocyanatePDTphotosensitizerphthalocyanine

Identifiers

PMID33132689
PMCPMC7598017
OpenAlexW2911891226

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.