ArticleEBioMedicine2020
Hypertension is associated with reduced hippocampal connectivity and impaired memory.
Article in EBioMedicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 3 of them syntheses that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
30 citing papers in PubMed, 3 syntheses or guidelines pooled it, 44 citations in OpenAlex.
- Is hypertension negatively associated with memory performance in women during climacteric? A systematic review.BMC women's health · 2025Pooled it
- Meta-Analysis and Multivariate GWAS Analyses in 80,950 Individuals of African Ancestry Identify Novel Variants Associated with Blood Pressure Traits.International journal of molecular sciences · 2023Pooled it
- Incidence of cognitive impairment post first stroke: a systematic review and meta-analysis.Frontiers in neurologyPooled it
- The role of metabolic health in neurostructural and cognitive alterations in bipolar disorders.Psychological medicine · 2026Article
- The Myokine Irisin Represents an Indirect Pathway Linking Exercise to Hippocampal Subfields Relevant to Alzheimer's Disease and Neurogenesis.Aging cell · 2026Article
- Article
- Preeclampsia as a reversible risk factor for Alzheimer's disease: A prospective MRI study on morphological changes of the cerebral cortex and impairment of cognitive functions.The journal of prevention of Alzheimer's disease · 2026Article
- Association Between Carotid Atherosclerosis and Post-Stroke Cognitive Impairment in Patients With Mild Ischemic Stroke: A Prospective Cohort Study.CNS neuroscience & therapeutics · 2026Article
- The association between mean arterial pressure and memory decline in preeclampsia patients: a mediation analysis of serum amyloid-β 1-42 and phosphorylated tau 181.BMC pregnancy and childbirth · 2025Article
- Control of Pulse Pressure and Factors Affecting it among the Geriatric Population Suffering from Hypertension within the Community.Reviews in cardiovascular medicine · 2025Article
- Electroacupuncture treatment can improve cognitive impairment in spontaneously hypertensive rats: a preliminary DTI study.Frontiers in neuroscience · 2025Article
- Remembering what did not happen: the role of hypnosis in memory recall and false memories formation.Frontiers in psychology · 2025Review
- An Investigation of the Relationship Between Vascular Markers and Cognitive Functions in Early Hypertension.Journal of personalized medicine · 2024Article
- Age-Related Effects of AT1 Receptor Antagonist Losartan on Cognitive Decline in Spontaneously Hypertensive Rats.International journal of molecular sciences · 2024Article
- Hypertension is associated with reduced resting-state medial temporal lobe dynamic network flexibility in older African Americans.Physiological reports · 2024Article
- Multispectral brain connectivity during visual attention distinguishes controlled from uncontrolled hypertension.The Journal of physiology · 2024Article
- Short-term blood pressure variability and brain functional network connectivity in older adults.Neuroimage. Reports · 2024Article
- Different cortical connectivities in human females and males relate to differences in strength and body composition, reward and emotional systems, and memory.Brain structure & function · 2024Article
- A functional connectome signature of blood pressure in >30 000 participants from the UK biobank.Cardiovascular research · 2023Article
- Predisposition to cortical neurodegenerative changes in brains of hypertension prone rats.Journal of translational medicine · 2023Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundThe objective was a large-scale analysis of the relation between hypertension, memory problems, and brain function.
methodsThe study design was to measure the association between a history of hypertension, and the functional connectivity between 94 brain regions, and prospective and numeric memory, in 19,507 participants from the UK Biobank, with cross-validation in 1,002 participants in the Human Connectome Project, and 13,441 individuals in the second release of the UK Biobank. A history of hypertension was measured by whether individuals were admitted to hospital for the treatment of hypertension, with the control group admissions for other reasons.
findingsA history of hypertension was associated with reduced functional connectivity of the hippocampus, and with reduced prospective memory score (FDR correction p<0.01). The reduced functional connectivity mediated the association between the hypertension history and the prospective memory score. A graded linear relation between both the hippocampal functional connectivity and memory impairment, was found across a wide range of blood pressure (r=-0.04). In 502,537 participants from the UK Biobank, a history of hypertension was associated with impaired prospective memory (p = 9.1 × 10
interpretationThe reduced functional connectivity of the hippocampus, and the memory impairments, both related to hypertension across a wide range of blood pressure, are important for clinical practice.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.