Evidence map›Paper›PMID 33131794›Full record

ArticleInjury2021

Prediction of severe chest injury using natural language processing from the electronic health record.

Sujay Kulshrestha, Dmitriy Dligach, Cara Joyce, Marshall S Baker, Richard Gonzalez, Ann P O'Rourke, Joshua M Glazer, Anne Stey, Jacqueline M Kruser, Matthew M Churpek and 1 more

Abstract read
In one paragraph

Article in Injury, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Observational
  7. Article
  8. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Sujay KulshresthaBurn and Shock Trauma Research Institute, Loyola University Chicago, CTRE Building 115, Room 315, 2160 South 1st Avenue, Maywood, IL, United States; Department of Surgery, Loyola University Medical Center, EMS Building 110, Room 3210, 2160 South 1st Avenue, Maywood, IL, United States. Electronic address: sujay.kulshrestha@lumc.edu.
Dmitriy DligachCenter for Health Outcomes and Informatics Research, Health Sciences Division, Loyola University Chicago, CTRE Building 115, Room 126, 2160 South 1st Avenue, Maywood, IL, United States; Department of Public Health Sciences, Stritch School of Medicine, Loyola University Chicago, 2160 South 1st Avenue, Maywood, IL, United States; Department of Computer Science, Loyola University Chicago, 1052 West Loyola Avenue, Chicago, IL, United States.
Cara JoyceCenter for Health Outcomes and Informatics Research, Health Sciences Division, Loyola University Chicago, CTRE Building 115, Room 126, 2160 South 1st Avenue, Maywood, IL, United States; Department of Public Health Sciences, Stritch School of Medicine, Loyola University Chicago, 2160 South 1st Avenue, Maywood, IL, United States.
Marshall S BakerDepartment of Surgery, Loyola University Medical Center, EMS Building 110, Room 3210, 2160 South 1st Avenue, Maywood, IL, United States; Veterans Affairs Hospital, 5000 South Fifth Avenue, Hines, IL, United States.
Richard GonzalezBurn and Shock Trauma Research Institute, Loyola University Chicago, CTRE Building 115, Room 315, 2160 South 1st Avenue, Maywood, IL, United States; Department of Surgery, Loyola University Medical Center, EMS Building 110, Room 3210, 2160 South 1st Avenue, Maywood, IL, United States.
Ann P O'RourkeDepartment of Surgery, University of Wisconsin, 600 Highland Avenue, MC 3236, Madison, WI, United States.
Joshua M GlazerDepartment of Emergency Medicine, University of Wisconsin, 800 University Bay Drive, Suite 310, MC 9123, Madison, WI, United States.
Anne SteyDivision of Trauma and Surgical Critical Care, Department of Surgery, Northwestern University, 76 North St. Clair Street, Suite 650, Chicago, IL, United States.
Jacqueline M KruserDivision of Pulmonary and Critical Care, Department of Medicine, Northwestern University, 633 North St. Clair Street, 20th Floor, McGaw M-335, Chicago, IL, United States; Department of Medical Social Sciences, Northwestern University, 633 North St. Clair Street, 19th Floor, Chicago, IL, United States.
Matthew M ChurpekDepartment of Medicine, University of Wisconsin, 8007 Excelsior Drive, Madison, WI, United States.
Majid AfsharCenter for Health Outcomes and Informatics Research, Health Sciences Division, Loyola University Chicago, CTRE Building 115, Room 126, 2160 South 1st Avenue, Maywood, IL, United States; Department of Health Informatics and Data Science, Loyola University Chicago, 2160 South First Avenue, Maywood, IL, United States.

Funding

The Institute for Translational MedicineUL1TR002389 · NCATS · UNIVERSITY OF CHICAGO · PI Joshua J Jacobs, DAVID O MELTZER · 2017 to 2026
$71.6M
Temporal relation discovery for clinical textR01LM010090 · NLM · BOSTON CHILDREN'S HOSPITAL · PI MARTIN, JAMES H., SAVOVA, GUERGANA K. · 2010 to 2022
$7.1M
Training in Neuroimmunoendocrine Effects of AlcoholT32AA013527 · NIAAA · LOYOLA UNIVERSITY CHICAGO · PI CHOUDHRY, MASHKOOR A · 2002 to 2021
$4.4M
Learning Universal Patient Representations with Hierarchical TransformersR01LM012973 · NLM · BOSTON CHILDREN'S HOSPITAL · PI Timothy A Miller · 2019 to 2026
$3.5M
Sepsis Early Prediction and Subphenotype Illumination Study (SEPSIS)R01GM123193 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI CHURPEK, MATTHEW MICHAEL · 2017 to 2021
$1.9M
CHANGE OF GRANTEE INSTITUTION 1 K23 AA024503 Alcohol, Burn-Injury, and Acute Respiratory Distress SyndromeK23AA024503 · NIAAA · UNIVERSITY OF WISCONSIN-MADISON · PI AFSHAR, MAJID · 2016 to 2020
$948k
NCATS NIH HHS UL1 TR002389NIAAA NIH HHS K23 AA024503NIAAA NIH HHS T32 AA013527NIGMS NIH HHS R01 GM123193NLM NIH HHS R01 LM010090NLM NIH HHS R01 LM012973
6 · The paper itself

Abstract

introductionTrauma injury severity scores are currently calculated retrospectively from the electronic health record (EHR) using manual annotation by certified trauma coders. Natural language processing (NLP) of clinical documents in the EHR may enable automated injury scoring. We hypothesize that NLP with machine learning can discriminate between cases of severe and non-severe injury to the thorax after trauma.

methodsClinical documents from a trauma center were examined between 2014 and 2018. Severe chest injury was defined as a thorax abbreviated injury score (AIS) >2 and served as the reference standard for supervised learning. Free text unigrams and concept unique identifiers (CUIs) from the Unified Medical Language Systems (UMLS) were extracted from clinical documents collected at one hour, four hours, and eight hours after patient arrival to the emergency department. Logistic regression models with elastic net regularization were tuned to maximize area under the receiver operating characteristic curve (AUROC) using 10-fold cross-validation on the training dataset (80%) and tested on a hold-out 20% dataset.

resultsThere were 6,891 traumas that met inclusion criteria. The complete data corpus consisted of 473,694 documents. Models trained using the first hour of data had a mean AUROC of 0.88 (95%CI [0.86, 0.89]); model discrimination and reclassification from the first hour significantly improved after eight hours with a mean AUROC of 0.94 (95%CI [0.93, 0.95]). Performance of models using CUIs were similar to unigrams (p>0.05). Models demonstrated excellent clinical face validity.

conclusionsBoth CUIs and unigrams demonstrated excellent discrimination in predicting severity of chest injury using the first eight hours of clinical documents. Our model demonstrates that automated anatomical injury scoring is feasible and may be used for aggregation of data for trauma research and quality programs.

Indexed as

Natural Language ProcessingThoracic InjuriesElectronic Health RecordsHumansRetrospective StudiesUnified Medical Language SystemMachine learningNatural language processingTraumaTrauma registry

Identifiers

PMID33131794
PMCPMC7856032

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.