Evidence map›Paper›PMID 33131493›Full record

ArticleBMC pediatrics2020

Risk factors associated with renal crescentic formation in pediatric Henoch-Schönlein purpura nephritis: a retrospective cohort study.

Yong-Rui Song, Wan-Liang Guo, Mao Sheng, Qiang Lin, Xue-Ming Zhu, Xiao-Zhong Li

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC pediatrics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.4field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Trial
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  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Yong-Rui SongDepartment of Radiology, Children's Hospital of Soochow University, 92 Zhongnan Street, Suzhou, 215025, Jiangsu, China.
Wan-Liang GuoDepartment of Radiology, Children's Hospital of Soochow University, 92 Zhongnan Street, Suzhou, 215025, Jiangsu, China.
Mao ShengDepartment of Radiology, Children's Hospital of Soochow University, 92 Zhongnan Street, Suzhou, 215025, Jiangsu, China.
Qiang LinDepartment of Nephrology and Immunology, Children's Hospital of Soochow University, 303 Jingde Road, Suzhou, 215003, Jiangsu, China.
Xue-Ming ZhuDepartment of Pathology, Children's Hospital of Soochow University, 92 Zhongnan Street, Suzhou, 215025, Jiangsu, China.
Xiao-Zhong LiDepartment of Nephrology and Immunology, Children's Hospital of Soochow University, 303 Jingde Road, Suzhou, 215003, Jiangsu, China. xiaozhonglicn@yeah.net.ORCID 0000-0002-2911-7814
Soochow University · CN

Funding

Key Laboratory of Children Kidney Pathology in Suzhou SZS201511Suzhou Science and Technology Plan Project in 2018, Key Laboratory for Diagnosis and Treatment of Children's Immune Diseases in Suzhou SZS201808
6 · The paper itself

Abstract

backgroundThe long-term prognosis of Henoch-Schönlein purpura (HSP) depends on the severity of renal involvement, and crescent formation is considered an important risk factor for poor prognosis of Henoch-Schönlein purpura nephritis (HSPN). The objective of this study was to evaluate factors affecting crescent formation in children with HSPN.

methodsDemographic factors, clinical characteristics, and laboratory data of children with HSPN with or without crescents were retrospectively analyzed. Univariate and multivariate logistic regression analyses were used to determine the risk factors of crescent formation in HSPN.

resultsA total of 191 children with HSPN were enrolled in the study. There were 107 (56%) males and 84 (44%) females, with a median age of 7 years (range: 2 years-15 years). International Study of Kidney Disease in Children (ISKDC) grading was used to divide subjects into two groups: those without glomerular crescent formation (ISKDC grades I-II, n = 146 cases) and those with glomerular crescent formation (ISKDC grades III-V, n = 45 cases). Logistic regression analysis showed that higher urinary white blood cell (WBC) count (OR = 3.300; 95% CI, 1.119-9.739; P = 0.0306) and higher urinary microalbumin/creatinine ratio (ACR) (OR = 25.053; 95% CI, 1.354-463.708; P = 0.0305) were independent risk factors for the formation of crescents in HSPN. The area under the receiver operating characteristic curve of urinary WBC and ACR were 0.753 and 0.698 respectively, with the Hosmer and Lemeshow goodness-of-fit test (P = 0.0669, P > 0.05).

conclusionThese results suggest that higher urinary WBC count and ACR should be strictly monitored for children with HSPN. Adequate clinical intervention for these risk factors may limit or prevent renal crescent formation.

Indexed as

GlomerulonephritisIgA VasculitisNephritisChildChild, PreschoolFemaleHumansKidneyMaleRetrospective StudiesRisk FactorsCrescent formationHenoch-Schönlein purpura nephritisHSPNRisk factors

Identifiers

PMID33131493
PMCPMC7604931
OpenAlexW3095210758

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.