Evidence map›Paper›PMID 33131406›Full record

ArticleCell cycle (Georgetown, Tex.)2020

Intravital imaging reveals cell cycle-dependent myogenic cell migration during muscle regeneration.

Yumi Konagaya, Kanako Takakura, Maina Sogabe, Anjali Bisaria, Chad Liu, Tobias Meyer, Atsuko Sehara-Fujisawa, Michiyuki Matsuda, Kenta Terai

Open access · bronzeAbstract read
In one paragraph

Article in Cell cycle (Georgetown, Tex.), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Imaging analysis for muscle stem cells and regeneration.Frontiers in cell and developmental biology · 2024
    Review
  6. Article
  7. Review
  8. Multiphoton intravital microscopy of rodents.Nature reviews. Methods primers · 2022
    Article
  9. Imaging developmental cell cycles.Biophysical journal · 2021
    Review
  10. Cells · 2021
    Review
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Yumi KonagayaDepartment of Chemical and Systems Biology, Stanford University School of Medicine , Stanford, CA, USA.ORCID 0000-0002-6631-2002
Kanako TakakuraImaging Platform for Spatio-Temporal Regulation, Graduate School of Medicine, Kyoto University , Kyoto, Japan.
Maina SogabeDepartment of Regeneration Science and Engineering, Institute of Frontier Life and Medical Sciences, Kyoto University , Kyoto, Japan.ORCID 0000-0002-0341-8088
Anjali BisariaDepartment of Chemical and Systems Biology, Stanford University School of Medicine , Stanford, CA, USA.ORCID 0000-0002-9709-9558
Chad LiuDepartment of Chemical and Systems Biology, Stanford University School of Medicine , Stanford, CA, USA.ORCID 0000-0002-8345-8847
Tobias MeyerDepartment of Chemical and Systems Biology, Stanford University School of Medicine , Stanford, CA, USA.ORCID 0000-0003-4339-3804
Atsuko Sehara-FujisawaDepartment of Regeneration Science and Engineering, Institute of Frontier Life and Medical Sciences, Kyoto University , Kyoto, Japan.
Michiyuki MatsudaLaboratory of Bioimaging and Cell Signaling, Graduate School of Biostudies, Kyoto University , Kyoto, Japan.ORCID 0000-0002-5876-9969
Kenta TeraiLaboratory of Bioimaging and Cell Signaling, Graduate School of Biostudies, Kyoto University , Kyoto, Japan.ORCID 0000-0001-7638-3720
Kyoto University · JPStanford University · US

Funding

Cell Signaling and Cell DecisionsR35GM127026 · NIGMS · WEILL MEDICAL COLL OF CORNELL UNIV · PI TOBIAS MEYER · 2018 to 2026
$8.5M
NIGMS NIH HHS R35 GM127026
6 · The paper itself

Abstract

During muscle regeneration, extracellular signal-regulated kinase (ERK) promotes both proliferation and migration. However, the relationship between proliferation and migration is poorly understood in this context. To elucidate this complex relationship on a physiological level, we established an intravital imaging system for measuring ERK activity, migration speed, and cell-cycle phases in mouse muscle satellite cell-derived myogenic cells. We found that

Indexed as

AnimalsCardiotoxinsCell CycleCell LineCell MovementCell ProliferationCyclin-Dependent Kinase 2Epithelial CellsExtracellular Signal-Regulated MAP KinasesFemaleHumansIntravital MicroscopyMaleMAP Kinase Signaling SystemMiceMice, TransgenicCardiotoxinsCdk2 protein, mouseCyclin-Dependent Kinase 2Extracellular Signal-Regulated MAP KinasesCDKcell cyclecell migrationERKintravital imagingSkeletal muscle regeneration

Identifiers

PMID33131406
PMCPMC7714504
OpenAlexW3095286338

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.