Trial reportHypertension (Dallas, Tex. : 1979)2020
Long-Term Blood Pressure Variability and Risk of Cardiovascular Disease Events Among Community-Dwelling Elderly.
Trial report in Hypertension (Dallas, Tex. : 1979), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 48 citations in OpenAlex.
- Use of Antihypertensives, Blood Pressure, and Estimated Risk of Dementia in Late Life: An Individual Participant Data Meta-Analysis.JAMA network open · 2023Pooled it
- Long-Term Blood Pressure Variability and Kidney Function in Participants of the ASPREE Trial.American journal of hypertension · 2022Trial
- Sex modifies the association between blood pressure variability and lung function decline among population over 45 years old: a pooled analysis of two national cohorts.Journal of thoracic disease · 2026Article
- Blood pressure variability will start cognitive impairment.Hypertension research : official journal of the Japanese Society of Hypertension · 2026Article
- Associations between gut microbiome and 24-hour blood pressure variability: a cross-sectional study highlighting sex differences and potential therapeutic targets.Gut microbiome (Cambridge, England) · 2026Article
- Research progress on the correlation between blood pressure variability and hypertensive microvascular disease.Frontiers in cardiovascular medicine · 2026Review
- Late-life, visit-to-visit blood pressure variability and its association with sex-specific long-term cognitive outcomes.Journal of human hypertension · 2025Article
- Article
- The Association Between Short-Term Blood Pressure Variability and Inflammation in Healthy Young Adults.Journal of cardiovascular development and disease · 2025Article
- Blood Pressure Postural Changes Variability Is Associated With Lower Cognition: The S.AGES Cohort.Journal of the American Heart Association · 2025Article
- Long-Term Blood Pressure Variability and Physical Performance in Older Adults.Journal of clinical hypertension (Greenwich, Conn.) · 2025Observational
- The association between the gut microbiome and 24-h blood pressure measurements in the SCAPIS study.Communications medicine · 2025Article
- Visit-to-Visit Blood Pressure Variability as a Risk Factor for All-Cause Mortality, Cardiovascular Mortality, and Major Adverse Cardiovascular Events Among American Indians: the Strong Heart Study.Preventing chronic disease · 2025Article
- The Dose-response of Blood Pressure Variability in Stroke and Coronary Heart Disease.Current hypertension reviews · 2025Article
- How blood pressure variation is associated with frailty and mortality in the elderly.Hypertension research : official journal of the Japanese Society of Hypertension · 2024Article
- Systolic blood pressure visit-to-visit variability and outcomes in Asian patients with atrial fibrillation.Hypertension research : official journal of the Japanese Society of Hypertension · 2024Article
- Pulse Wave Velocity and Blood Pressure Variability as Prognostic Indicators in Very Elderly Patients.Journal of clinical medicine · 2023Article
- Variation in Mean Arterial Pressure Increases Falls Risk in Elderly Physically Frail and Prefrail Individuals Treated With Antihypertensive Medication.Hypertension (Dallas, Tex. : 1979) · 2022Article
- Application of ensemble machine learning algorithms on lifestyle factors and wearables for cardiovascular risk prediction.Scientific reports · 2022Article
- Blood pressure visit-to-visit variability and outcomes in patients with heart failure with preserved ejection fraction.ESC heart failure · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 6 institutions in 2 countries.
Funding
Abstract
High office blood pressure variability (OBPV) in midlife increases the risk of cardiovascular disease (CVD), but the impact of OBPV in older adults without previous CVD is unknown. We conducted a post hoc analysis of ASPREE trial (Aspirin in Reducing Events in the Elderly) participants aged 70-years and older (65 for US minorities) without history of CVD events at baseline, to examine risk of incident CVD associated with long-term, visit-to-visit OBPV. CVD was a prespecified, adjudicated secondary end point in ASPREE. We estimated OBPV using within-individual SD of mean systolic BP from baseline and first 2 annual visits. Cox proportional hazards regression was used to calculate hazard ratios (HR) and 95% CI for associations with CVD events. In 16 475 participants who survived to year 2 without events, those in the highest tertile of OBPV had increased risk of CVD events after adjustment for multiple covariates, when compared with participants in the lowest tertile (HR, 1.36 [95% CI, 1.08-1.70];
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.