Evidence map›Paper›PMID 33130982›Full record

ArticleJournal of materials science. Materials in medicine2020

ZnO-mesoporous glass scaffolds loaded with osteostatin and mesenchymal cells improve bone healing in a rabbit bone defect.

D Lozano, J Gil-Albarova, C Heras, S Sánchez-Salcedo, V E Gómez-Palacio, A Gómez-Blasco, J C Doadrio, M Vallet-Regí, A J Salinas

Open access · greenAbstract read
PubMed Publisher
In one paragraph

Article in Journal of materials science. Materials in medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.0field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 21 citations in OpenAlex.

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  11. Strategies for Bone Regeneration: From Graft to Tissue Engineering.International journal of molecular sciences · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

D LozanoDepartment of Chemistry in Pharmaceutical Sciences, Universidad Complutense, UCM; Instituto Investigación Sanitaria Hospital 12 de Octubre, imas12, Madrid, Spain.
J Gil-AlbarovaServicio de Cirugía Ortopédica y Traumatología, Hospital Universitario Miguel Servet, Zaragoza, Spain. jgilalba@unizar.es.
C HerasDepartment of Chemistry in Pharmaceutical Sciences, Universidad Complutense, UCM; Instituto Investigación Sanitaria Hospital 12 de Octubre, imas12, Madrid, Spain.
S Sánchez-SalcedoDepartment of Chemistry in Pharmaceutical Sciences, Universidad Complutense, UCM; Instituto Investigación Sanitaria Hospital 12 de Octubre, imas12, Madrid, Spain.
V E Gómez-PalacioServicio de Cirugía Ortopédica y Traumatología, Hospital Universitario Miguel Servet, Zaragoza, Spain.
A Gómez-BlascoServicio de Cirugía Ortopédica y Traumatología, Hospital Universitario Miguel Servet, Zaragoza, Spain.
J C DoadrioDepartment of Chemistry in Pharmaceutical Sciences, Universidad Complutense, UCM; Instituto Investigación Sanitaria Hospital 12 de Octubre, imas12, Madrid, Spain.
M Vallet-RegíDepartment of Chemistry in Pharmaceutical Sciences, Universidad Complutense, UCM; Instituto Investigación Sanitaria Hospital 12 de Octubre, imas12, Madrid, Spain.
A J SalinasDepartment of Chemistry in Pharmaceutical Sciences, Universidad Complutense, UCM; Instituto Investigación Sanitaria Hospital 12 de Octubre, imas12, Madrid, Spain. salinas@ucm.es.
Research Institute Hospital 12 de Octubre · ESHospital Universitario Miguel Servet · ESBiomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine · ESUniversidad Complutense de Madrid · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The use of 3D scaffolds based on mesoporous bioactive glasses (MBG) enhanced with therapeutic ions, biomolecules and cells is emerging as a strategy to improve bone healing. In this paper, the osteogenic capability of ZnO-enriched MBG scaffolds loaded or not with osteostatin (OST) and human mesenchymal stem cells (MSC) was evaluated after implantation in New Zealand rabbits. Cylindrical meso-macroporous scaffolds with composition (mol %) 82.2SiO

Indexed as

AnimalsBiocompatible MaterialsBone RegenerationFemaleFractures, BoneGlassIonsMaterials TestingMesenchymal Stem CellsOsteogenesisParathyroid Hormone-Related ProteinPeptide FragmentsPorosityRabbitsTissue ScaffoldsX-Ray MicrotomographyBiocompatible MaterialsIonsParathyroid Hormone-Related Proteinparathyroid hormone-related protein (107-111)Peptide FragmentsZincZinc Oxide

Identifiers

PMID33130982
OpenAlexW3097535709

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.