Evidence map›Paper›PMID 33130942›Full record

ArticleJournal of cancer research and clinical oncology2021

The impact of low-volume metastasis on disease-free survival of women with early-stage cervical cancer.

Alessandro Buda, Jvan Casarin, Michael Mueller, Francesco Fanfani, Ignacio Zapardiel, Liliana Mereu, Andrea Puppo, Elena De Ponti, Marco Adorni, Debora Ferrari and 4 more

Erratum issuedOpen access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cancer research and clinical oncology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
0.4field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.

  1. Pooled it
  2. MILACC study: could undetected lymph node micrometastases have impacted recurrence rate in the LACC trial?International journal of gynecological cancer : official journal of the International Gynecological Cancer Society · 2023
    Trial
  3. Article
  4. Article
  5. Review
  6. Article
  7. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors at 8 institutions in 3 countries.

Alessandro BudaGynecology Oncology Surgical Unit, Department of Obstetrics and Gynecology, San Gerardo Hospital, University of Milano-Bicocca, Monza, Italy. alebuda1972@gmail.com.ORCID http://orcid.org/0000-0002-7093-6862
Jvan CasarinObstetrics and Gynecology Department, University of Insubria, Varese, Italy.
Michael MuellerDepartment of Obstetrics and Gynecology, University Hospital of Bern and University of Bern, Bern, Switzerland.
Francesco FanfaniDipartimento della salute della donna, del bambino e di sanità pubblica, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.
Ignacio ZapardielGynecologic Oncology Unit, La Paz University Hospital-IdiPAZ, Madrid, Spain.
Liliana MereuDepartment of Obstetrics and Gynecology, Santa Chiara Hospital, Trento, Italy.
Andrea PuppoClinic of Obstetrics and Gynecology, Santa Croce e Carle Hospital, Cuneo, Italy.
Elena De PontiDepartment of Physical Medicine, San Gerardo Hospital, University of Milano-Bicocca, Monza, Italy.
Marco AdorniGynecology Oncology Surgical Unit, Department of Obstetrics and Gynecology, San Gerardo Hospital, University of Milano-Bicocca, Monza, Italy.
Debora FerrariGynecology Oncology Surgical Unit, Department of Obstetrics and Gynecology, San Gerardo Hospital, University of Milano-Bicocca, Monza, Italy.
Maria Luisa GasparriDepartment of Gynecology and Obstetrics, University of the Italian Switzerland (USI), Ente Ospedaliero Cantonale of Lugano, Lugano, Switzerland.
Fabio GhezziObstetrics and Gynecology Department, University of Insubria, Varese, Italy.
Giovanni ScambiaDipartimento della salute della donna, del bambino e di sanità pubblica, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.
Andrea PapadiaDepartment of Obstetrics and Gynecology, University Hospital of Bern and University of Bern, Bern, Switzerland.
University of Milano-Bicocca · ITUniversità Cattolica del Sacro Cuore · ITUniversity of Bern · CHUniversity of Insubria · ITAzienda Sanitaria Ospedaliera S.Croce e Carle Cuneo · ITEnte Ospedaliero Cantonale · CHHospital Universitario La Paz · ESOspedale Santa Chiara · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeWe aimed to assess the impact of low-volume metastasis (micrometastasis and isolated tumor cells) on disease-free survival (DFS) of women with early-stage cervical cancer.

methodsWomen with clinically suspected stage 1A-IB2 (FIGO 2018 classification) disease who underwent retroperitoneal nodal staging between October 2010 and April 2018, were retrospectively analyzed. The group of women who had undergone lymphadenectomy and standard node pathologic analysis (H&E group), were compared to the group undergoing sentinel node mapping (SLN) and ultrastaging with or without lymphadenectomy (ultrastaging group). At a median follow-up of 45 months, the DFS curves were analyzed.

resultsOverall, 573 patients were revised (272 in the H&E group and 302 in the ultrastaging group). Eighty-five patients presented lymph node metastasis (32 in H&E, 53 in ultrastaging). Ultrastaging protocol increased the rate of low-volume metastasis by 5.6%. Twenty patients showed exclusive micrometastasis or ITC's. Seventy-three recurrences occurred (35 in H&E, 38 in ultrastaging). Only 1 out of 53 patients in the ultrastaging group (1.9%) presented with micrometastasis recurred. The 3-year disease-free survival was 89% for the H&E group, and 88% for the ultrastaging group, respectively (p = 0.175).

conclusionUltrastaging analysis allowed increasing the detection of low volume metastasis in women with early-stage cervical cancer. However, the type of nodal staging did not have an impact on patients' 3-year disease-free survival.

Indexed as

AdenocarcinomaAdultCarcinoma, AdenosquamousCarcinoma, Squamous CellCase-Control StudiesDisease-Free SurvivalFemaleHumansLymphatic MetastasisLymph NodesMiddle AgedNeoplasm MicrometastasisNeoplasm StagingPrognosisRetrospective StudiesSentinel Lymph Node BiopsyCervical cancerLow volume metastasesProgression-free survivalSentinel node

Identifiers

PMID33130942
PMCPMC11802125
OpenAlexW3097350410

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.