Evidence map›Paper›PMID 33130938›Full record

ReviewCurrent genetics2021

Rules are made to be broken: a "simple" model organism reveals the complexity of gene regulation.

Andrea L Higdon, Gloria A Brar

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Current genetics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Andrea L HigdonDepartment of Molecular and Cell Biology, University of California, Berkeley, CA, 94720, USA.
Gloria A BrarDepartment of Molecular and Cell Biology, University of California, Berkeley, CA, 94720, USA. gabrar@berkeley.edu.ORCID http://orcid.org/0000-0002-8560-9581

Funding

Illuminating the gene regulatory strategies underlying yeast meiosis and beyondR35GM134886 · NIGMS · UNIVERSITY OF CALIFORNIA BERKELEY · PI Gloria Ann Brar · 2020 to 2026
$3.1M
National Science Foundation DGE 1752814NIGMS NIH HHS 1R35GM134886NIGMS NIH HHS R35 GM134886
6 · The paper itself

Abstract

Global methods for assaying translation have greatly improved our understanding of the protein-coding capacity of the genome. In particular, it is now possible to perform genome-wide and condition-specific identification of translation initiation sites through modified ribosome profiling methods that selectively capture initiating ribosomes. Here we discuss our recent study applying such an approach to meiotic and mitotic timepoints in the simple eukaryote, budding yeast, as an example of the surprising diversity of protein products-many of which are non-canonical-that can be revealed by such methods. We also highlight several key challenges in studying non-canonical protein isoforms that have precluded their prior systematic discovery. A growing body of work supports expanded use of empirical protein-coding region identification, which can help relieve some of the limitations and biases inherent to traditional genome annotation approaches. Our study also argues for the adoption of less static views of gene identity and a broader framework for considering the translational capacity of the genome.

Indexed as

Gene Expression Regulation, FungalOpen Reading FramesProtein BiosynthesisRibosomesRNA, MessengerSaccharomyces cerevisiaeTranscriptomeRNA, MessengerGenome annotationMeiosisNear-cognate codonsProtein-coding regionsRibosome profilingTranslation initiation

Identifiers

PMID33130938
PMCPMC7887019

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.