Evidence map›Paper›PMID 33130575›Full record

ArticleJournal of neurology, neurosurgery, and psychiatry2021

Fronto-striatal circuits for cognitive flexibility in far from onset Huntington's disease: evidence from the Young Adult Study.

Christelle Langley, Sarah Gregory, Katie Osborne-Crowley, Claire O'Callaghan, Paul Zeun, Jessica Lowe, Eileanoir B Johnson, Marina Papoutsi, Rachael I Scahill, Geraint Rees and 3 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neurology, neurosurgery, and psychiatry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 2 pooled it
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 2 syntheses or guidelines pooled it, 49 citations in OpenAlex.

  1. Pooled it
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  10. Virtual reality tolerability, sense of presence and usability in Huntington disease: a pilot study.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025
    Article
  11. Article
  12. Mild cognitive impairment in Huntington's disease: challenges and outlooks.Journal of neural transmission (Vienna, Austria : 1996) · 2024
    Review
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 2 countries.

Christelle LangleyDepartment of Psychiatry, University of Cambridge, Cambridge, UK cl798@medschl.cam.ac.uk.ORCID 0000-0001-5061-2820
Sarah GregoryHuntington's Disease Centre, Department of Neurodegenerative disease, Institute of Neurology, University College London, London, UK.ORCID 0000-0003-4620-6963
Katie Osborne-CrowleyHuntington's Disease Centre, Department of Neurodegenerative disease, Institute of Neurology, University College London, London, UK.ORCID 0000-0003-3596-4363
Claire O'CallaghanDepartment of Psychiatry, University of Cambridge, Cambridge, UK.ORCID 0000-0001-5698-6364
Paul ZeunHuntington's Disease Centre, Department of Neurodegenerative disease, Institute of Neurology, University College London, London, UK.
Jessica LoweHuntington's Disease Centre, Department of Neurodegenerative disease, Institute of Neurology, University College London, London, UK.
Eileanoir B JohnsonHuntington's Disease Centre, Department of Neurodegenerative disease, Institute of Neurology, University College London, London, UK.
Marina PapoutsiHuntington's Disease Centre, Department of Neurodegenerative disease, Institute of Neurology, University College London, London, UK.
Rachael I ScahillHuntington's Disease Centre, Department of Neurodegenerative disease, Institute of Neurology, University College London, London, UK.ORCID 0000-0002-1832-106X
Geraint ReesUniversity College London Institute of Cognitive Neuroscience, UCL, London, UK.ORCID 0000-0002-9623-7007
Sarah J TabriziHuntington's Disease Centre, Department of Neurodegenerative disease, Institute of Neurology, University College London, London, UK.ORCID 0000-0003-2716-2045
Trevor W RobbinsDepartment of Psychology and Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, UK.ORCID 0000-0003-0642-5977
Barbara Jacquelyn SahakianDepartment of Psychiatry, University of Cambridge, Cambridge, UK.ORCID 0000-0001-7352-1745
Huntington's Disease Association · GBUniversity of Cambridge · GBThe University of Sydney · AUUniversity College London · GBUNSW Sydney · AU

Funding

Wellcome Trust 200181/Z/15/Z
6 · The paper itself

Abstract

objectivesCognitive flexibility, which is key for adaptive decision-making, engages prefrontal cortex (PFC)-striatal circuitry and is impaired in both manifest and premanifest Huntington's disease (pre-HD). The aim of this study was to examine cognitive flexibility in a far from onset pre-HD cohort to determine whether an early impairment exists and if so, whether fronto-striatal circuits were associated with this deficit.

methodsIn the present study, we examined performance of 51 pre-HD participants (mean age=29.22 (SD=5.71) years) from the HD Young Adult Study cohort and 53 controls matched for age, sex and IQ, on the Cambridge Neuropsychological Test Automated Battery (CANTAB) Intra-Extra Dimensional Set-Shift (IED) task. This cohort is unique as it is the furthest from disease onset comprehensively studied to date (mean years=23.89 (SD=5.96) years). The IED task measures visual discrimination learning, cognitive flexibility and specifically attentional set-shifting. We used resting-state functional MRI to examine whether the functional connectivity between specific fronto-striatal circuits was dysfunctional in pre-HD, compared with controls, and whether these circuits were associated with performance on the critical extradimensional shift stage.

resultsOur results demonstrated that the CANTAB IED task detects a mild early impairment in cognitive flexibility in a pre-HD group far from onset. Attentional set-shifting was significantly related to functional connectivity between the ventrolateral PFC and ventral striatum in healthy controls and to functional connectivity between the dorsolateral PFC and caudate in pre-HD participants.

conclusionWe postulate that this incipient impairment of cognitive flexibility may be associated with intrinsically abnormal functional connectivity of fronto-striatal circuitry in pre-HD.

Indexed as

CognitionAdultCase-Control StudiesCorpus StriatumFemaleHumansHuntington DiseaseMagnetic Resonance ImagingMaleNeuroimagingNeuropsychological TestsPrefrontal CortexYoung Adult

Identifiers

PMID33130575
PMCPMC7841479
OpenAlexW3095250012

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.