Observational studyBMJ open2020
Impact of frailty on 30-day and 1-year mortality in hospitalised elderly patients with community-acquired pneumonia: a prospective observational study.
Observational study in BMJ open, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.
- Impact of frailty on pneumonia outcomes in older patients: a systematic review and meta-analysis.European geriatric medicine · 2024Pooled it
- Immune risk phenotype and long-term mortality after community-acquired pneumonia in older adults: clinical and immune determinants.Immunity & ageing : I & A · 2026Article
- Association of Frailty and Frailty Trajectory with Risk for Respiratory Infectious Diseases.Emerging infectious diseases · 2026Article
- Systemic corticosteroids for severe community-acquired pneumonia: a narrative review of mechanisms and critical appraisal of recent trials in ICU.European respiratory review : an official journal of the European Respiratory Society · 2026Review
- Frailty as a Key Determinant of In-Hospital Mortality in 58,040 Patients with Community-Acquired Pneumonia: Evidence from a Chilean Cohort.Journal of clinical medicine · 2026Article
- Treg/Th17 imbalance and its association with frailty in elderly patients with community-acquired pneumonia.Frontiers in medicine · 2026Article
- Comparing various frailty instruments for predicting adverse outcomes in older patients hospitalized with lower respiratory tract infections.The journal of nutrition, health & aging · 2026Article
- Predictive value of bedside lung ultrasound, quantitative chest CT, and frailty assessment for short-term outcomes in elderly patients with severe pneumonia: a pilot study.BMC pulmonary medicine · 2025Article
- Characteristics and trends of antibiotic resistance in several gram-negative bacteria responsible for pneumonia in intensive care patients in Northern Vietnam, 2022-2024.IJID regions · 2025Article
- Early Sitting Improves the Accuracy of Predicting In-Hospital Mortality in Older Adult Patients With Pneumonia.Cureus · 2025Article
- Association Between Pneumonia Risk and Anticholinergic Burden Among Patients with Different Frailty Levels.Clinical epidemiology · 2025Article
- Health-related quality of life predicts prognosis in individuals with COPD hospitalized with community-acquired pneumonia - a prospective cohort study.Scientific reports · 2024Article
- Assessing the Impact of Frailty on Infection Risk in Older Adults: Prospective Observational Cohort Study.JMIR public health and surveillance · 2024Observational
- Correlates of frailty in older female cancer survivors.Journal of geriatric oncology · 2024Article
- Validation of the Hospital Frailty Risk Score in older adults hospitalized with community-acquired pneumonia.Geriatrics & gerontology international · 2024Article
- Application of laboratory frailty index in predicting delirium in elderly patients with community-acquired pneumonia.Frontiers in aging · 2024Article
- Prognostic significance of frailty in hospitalized elderly patients with community-acquired pneumonia: a retrospective cohort study.BMC geriatrics · 2023Article
- Association of frailty with influenza and hospitalization due to influenza among independent older adults: a longitudinal study of Japan Gerontological Evaluation Study (JAGES).BMC geriatrics · 2023Article
- Association between Barthel Index, Grip Strength, and Physical Activity Level at Admission and Prognosis in Community-Acquired Pneumonia: A Prospective Cohort Study.Journal of clinical medicine · 2022Article
- Long-Term Effects of Hospitalization for COVID-19 on Frailty and Quality of Life in Older Adults ≥80 Years.Journal of clinical medicine · 2022Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThis study evaluates the impact of frailty, which is a state of increased vulnerability to stressors, on 30-day and 1-year mortality among elderly patients with community-acquired pneumonia (CAP). The main hypothesis is that frailty is an independent predictor of prognosis in elderly CAP patients.
designProspective, observational, follow-up cohort study.
settingA 2000-bed tertiary care hospital in Beijing, China.
participantsConsecutive CAP patients aged ≥65 years admitted to the geriatric department of our hospital between September 2017 and February 2019.
main outcome measuresThe primary outcomes were all-cause mortality at 30 days and 1 year after hospital admission. The impact of frailty (defined by frailty phenotype) on 30-day and 1-year mortality of elderly patients with CAP was assessed by Cox regression analysis.
resultsThe cohort included 256 patients. The median (IQR) age was 86 (81-90) years, and 180 (70.3%) participants were men. A total of 171/256 (66.8%) patients were frail. The prevalence of frailty was significantly associated with older age, female gender, lower body mass index, comorbidities, limitations in activities of daily living (ADLs) and poor nutritional status. Frail participants were significantly more likely to have severe CAP (SCAP) than non-frail counterparts (28.65% vs 9.41%, p<0.001). The 1-year mortality risk was approximately threefold higher in frail patients (adjusted HR, 2.70; 95% CI, 1.69 to 4.39) than non-frail patients. Subgroup analysis of patients with SCAP showed that the 1-year mortality risk was approximately threefold higher in the frail group (adjusted HR, 2.87; 95% CI, 1.58 to 4.96) than in the non-frail group. The association between frailty and 30-day mortality was not significant.
conclusionsThese findings suggest that frailty is strongly associated with SCAP and higher 1-year mortality in elderly patients with CAP, and frailty should be detected early to improve the management of these patients.
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