Evidence map›Paper›PMID 33130200›Full record

ArticleInternational journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases2021

Asymptomatic hypoxia in COVID-19 is associated with poor outcome.

Philippe Brouqui, Sophie Amrane, Matthieu Million, Sébastien Cortaredona, Philippe Parola, Jean-Christophe Lagier, Didier Raoult

Abstract read
In one paragraph

Article in International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 71 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
71citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

71 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Patients' and GPs' views and expectations of home monitoring with a pulse oximeter: a mixed-methods process evaluation of a pilot randomised controlled trial.The British journal of general practice : the journal of the Royal College of General Practitioners · 2023
    Trial
  5. Home monitoring by pulse oximetry of primary care patients with COVID-19: a pilot randomised controlled trial.The British journal of general practice : the journal of the Royal College of General Practitioners · 2023
    Trial
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Review
  15. Article
  16. Application of Non-Pharmacologic Therapy in Hair Loss Treatment and Hair Regrowth.Clinical, cosmetic and investigational dermatology · 2024
    Review
  17. Article
  18. Review
  19. Article
  20. Remote Patient Monitoring for COVID-19: A Retrospective Study on Health Care Utilization.Telemedicine journal and e-health : the official journal of the American Telemedicine Association · 2023
    Article

11 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Philippe BrouquiAix Marseille Université, IRD, MEPHI, Marseille, France; IHU-Mediterranée Infection, Marseille, France. Electronic address: philippe.brouqui@univ-amu.fr.
Sophie AmraneAix Marseille Université, IRD, MEPHI, Marseille, France; IHU-Mediterranée Infection, Marseille, France.
Matthieu MillionAix Marseille Université, IRD, MEPHI, Marseille, France; IHU-Mediterranée Infection, Marseille, France.
Sébastien CortaredonaIHU-Mediterranée Infection, Marseille, France; Aix Marseille Université, IRD, AP-HM, SSA, VITROME, Marseille, France.
Philippe ParolaIHU-Mediterranée Infection, Marseille, France; Aix Marseille Université, IRD, AP-HM, SSA, VITROME, Marseille, France.
Jean-Christophe LagierAix Marseille Université, IRD, MEPHI, Marseille, France; IHU-Mediterranée Infection, Marseille, France.
Didier RaoultAix Marseille Université, IRD, MEPHI, Marseille, France; IHU-Mediterranée Infection, Marseille, France.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesDescribe and evaluate the outcome of a coronavirus disease-2019 (COVID-19) patient without shortness of breath. DESIGN AND

methodsWe retrospectively collected data from COVID-19 patients diagnosed and cared for in Marseille, France. We selected data from patients who at admission, had a low dose CT scanner, dyspnea status, and oxygen saturation available. Blood gas was analyzed in a sample subset of patients.

resultsAmong 1712 patients with COVID-19, we report that 1107 (64.7%) do not complain of shortness of breath at admission. The low-dose computed tomography (LDCT) scan showed signs compatible with pneumonia in 757/1,107 (68.4%) of patients without dyspnea. In a subset of patients who had underwent at least one blood gas analysis (n = 161) and presented without dyspnea at admission, 28.1% (27/96) presented with a hypoxemia/hypocapnia syndrome. Asymptomatic hypoxia was associated with a very poor outcome (33.3% were transferred to the ICU and 25.9% died).

conclusionThe absence of shortness of breath in an old patient with comorbidity merit medical attention and should not be considered as a good sign of well-being. The poor prognosis of asymptomatic hypoxia, highlight the severity of this mild clinical presentation. In these patients, pulse oximetry is an important mean to predict the outcome along with news score and LDCT scanner.

Indexed as

SARS-CoV-2AgedAged, 80 and overAsymptomatic DiseasesCOVID-19DyspneaFemaleFranceHumansHypoxiaIntensive Care UnitsMaleMiddle AgedRetrospective StudiesTomography, X-Ray Computed02 satCOVID-19D-dimersHappyHypocapniaHypoxemiaHypoxiaLow dose CT-scan

Identifiers

PMID33130200
PMCPMC7604151

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.