Evidence map›Paper›PMID 33130170›Full record

ReviewEnvironmental research2021

Environmental exposures and sleep outcomes: A review of evidence, potential mechanisms, and implications.

Jianghong Liu, Lea Ghastine, Phoebe Um, Elizabeth Rovit, Tina Wu

Open access · greenAbstract readReview
In one paragraph

Review in Environmental research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
59citing papers in PubMed, 3 pooled it
3.0field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

59 citing papers in PubMed, 3 syntheses or guidelines pooled it, 115 citations in OpenAlex.

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  11. Ambient PMBMC public health · 2026
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  13. Association between PMFrontiers in public health · 2026
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  17. Impact of PMAnnals of medicine · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Jianghong LiuUniversity of Pennsylvania School of Nursing, 418 Curie Blvd, Philadelphia, PA, 19104, USA. Electronic address: jhliu@nursing.upenn.edu.
Lea GhastineOhio State University College of Medicine, 370 W 9th Ave, Columbus, OH, 43210, USA.
Phoebe UmOhio State University College of Medicine, 370 W 9th Ave, Columbus, OH, 43210, USA.
Elizabeth RovitUniversity of Pennsylvania School of Nursing, 418 Curie Blvd, Philadelphia, PA, 19104, USA.
Tina WuUniversity of Pennsylvania School of Nursing, 418 Curie Blvd, Philadelphia, PA, 19104, USA.
University of Pennsylvania · USThe Ohio State University · US

Funding

Translational Research Support CoreP30ES013508 · NIEHS · UNIVERSITY OF PENNSYLVANIA · PI Trevor M Penning · 2006 to 2026
$35.3M
Omega-3 Supplementation and Adolescent BehaviorR01HD087485 · NICHD · UNIVERSITY OF PENNSYLVANIA · PI LIU, JIANGHONG, RAINE, ADRIAN · 2017 to 2021
$2.5M
Steer and trees summer research programsR25ES021649 · NIEHS · UNIVERSITY OF PENNSYLVANIA · PI FIELD, JEFFREY M · 2013 to 2022
$830k
NICHD NIH HHS R01 HD087485NIEHS NIH HHS P30 ES013508NIEHS NIH HHS R25 ES021649
6 · The paper itself

Abstract

Environmental exposures and poor sleep outcomes are known to have consequential effects on human health. This integrative review first seeks to present and synthesize existing literature investigating the relationship between exposure to various environmental factors and sleep health. We then present potential mechanisms of action as well as implications for policy and future research for each environmental exposure. Broadly, although studies are still emerging, empirical evidence has begun to show a positive association between adverse effects of heavy metal, noise pollution, light pollution, second-hand smoke, and air pollution exposures and various sleep problems. Specifically, these negative sleep outcomes range from subjective sleep manifestations, such as general sleep quality, sleep duration, daytime dysfunction, and daytime sleepiness, as well as objective sleep measures, including difficulties with sleep onset and maintenance, sleep stage or circadian rhythm interference, sleep arousal, REM activity, and sleep disordered breathing. However, the association between light exposure and sleep is less clear. Potential toxicological mechanisms are thought to include the direct effect of various environmental toxicants on the nervous, respiratory, and cardiovascular systems, oxidative stress, and inflammation. Nevertheless, future research is required to tease out the exact pathways of action to explain the associations between each environmental factor and sleep, to inform possible therapies to negate the detrimental effects, and to increase efforts in decreasing exposure to these harmful environmental factors to improve health.

Indexed as

Air PollutionEnvironmental ExposureSleepCircadian RhythmHazardous SubstancesHumansHazardous SubstancesAir pollutionEnvironmental exposureHeavy metalsNoise and light pollutionSecond-hand smokeSleep

Identifiers

PMID33130170
PMCPMC8081760
OpenAlexW3097016281

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.