Evidence map›Paper›PMID 33130051›Full record

ArticleJournal of neuroscience methods2021

Protective cranial implant caps for macaques.

Brook A L Perry, Stuart Mason, Jennifer Nacef, Ashley Waddle, Brian Hynes, Caroline Bergmann, Michael C Schmid, Christopher I Petkov, Alexander Thiele, Anna S Mitchell

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neuroscience methods, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.5field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Social Housing of Postoperative Animals to Support Animal Welfare.Journal of the American Association for Laboratory Animal Science : JAALAS · 2026
    Review
  3. Article
  4. Review
  5. Review
  6. Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Brook A L PerryDepartment of Experimental Psychology, Oxford University, Tinsley Building, Oxford, OX1 3SR, UK.
Stuart MasonDepartment of Experimental Psychology, Oxford University, Tinsley Building, Oxford, OX1 3SR, UK.
Jennifer NacefBiosciences Institute, Newcastle University, Henry Wellcome Building, Newcastle upon Tyne, NE2 4HH, UK.
Ashley WaddleBiosciences Institute, Newcastle University, Henry Wellcome Building, Newcastle upon Tyne, NE2 4HH, UK.
Brian HynesHybex Innovations Inc., 9851 Boulevard Parkway, Anjou, Quebec, H1J 1P3, Canada.
Caroline BergmannBiomedical Services Department, Oxford University, Mansfield Road, Oxford, OX1 3TA, UK.
Michael C SchmidBiosciences Institute, Newcastle University, Henry Wellcome Building, Newcastle upon Tyne, NE2 4HH, UK; University of Fribourg, Faculty of Science and Medicine, Chemin du Musée 5, 1700, Fribourg, Switzerland.
Christopher I PetkovBiosciences Institute, Newcastle University, Henry Wellcome Building, Newcastle upon Tyne, NE2 4HH, UK.
Alexander ThieleBiosciences Institute, Newcastle University, Henry Wellcome Building, Newcastle upon Tyne, NE2 4HH, UK.
Anna S MitchellDepartment of Experimental Psychology, Oxford University, Tinsley Building, Oxford, OX1 3SR, UK. Electronic address: anna.mitchell@psy.ox.ac.uk.
Newcastle University · GBUniversity of Oxford · GB

Funding

Medical Research Council G0800329Medical Research Council MR/P013031/1National Centre for the Replacement, Refinement and Reduction of Animals in Research NC/P000940/1Wellcome TrustWellcome Trust 110157/Z/15/ZWellcome Trust WT092606AIAWellcome Trust WT093104
6 · The paper itself

Abstract

backgroundNeuroscience studies with macaque monkeys may require cranial implants to stabilize the head or gain access to the brain for scientific purposes. Wound management that promotes healing after the cranial implant surgery in non-human primates can be difficult as it is not necessarily possible to cover the wound margins. NEW

methodHere, we developed an easily modifiable head cap that protects the sutured skin margins after cranial implant surgery and contributes to wound healing. The protective head cap was developed in response to monkeys picking at sutured skin margins around an implant, complicating healing. The user-friendly protective cap, made from Klarity- R™ Sheet (3.2 mm thick with 36 % or 42 % perforation) is affixed to the implant post-surgically. Once secured and while the monkey is still anesthetized, the plastic sheeting is molded around the implant. The protective head cap restricts the monkey's finger access to its' wound margins while allowing air to circulate to promote wound healing. RESULTS AND COMPARISON WITH EXISTING

methodsAcross two UK primate facilities, the protective head cap promoted wound healing. In monkeys that did not wear the head cap, re-suturing was necessary in ∼30 % of cases. In contrast, none of the monkeys that wore the head cap required re-suturing. The monkeys wearing the head cap also had reduced numbers of days of prescribed antibiotics and analgesia.

conclusionThis bespoken, easily adaptable, protective head cap supports postoperative wound healing, and enhances the welfare of monkeys involved in neuroscience research.

Indexed as

Prostheses and ImplantsSkullAnimalsBrainHeadMacaca mulattaBehaviorCognitionMacaca mulattaNeuroimagingNeurophysiologyNeuroscienceNon-human primatePrimate chairWelfareWound management

Identifiers

PMID33130051
PMCPMC7840592
OpenAlexW3094778716

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.