Evidence map›Paper›PMID 33129662›Full record

ArticleThe International journal on drug policy2021

Overdose among mothers: The association between child removal and unintentional drug overdose in a longitudinal cohort of marginalised women in Canada.

Meaghan Thumath, David Humphreys, Jane Barlow, Putu Duff, Melissa Braschel, Brittany Bingham, Sophie Pierre, Kate Shannon

Open access · greenAbstract read
In one paragraph

Article in The International journal on drug policy, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed, 1 pooled it
13.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed, 1 synthesis or guideline pooled it, 93 citations in OpenAlex.

  1. Pooled it
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  8. Health Promotion and Support Grounded in Interconnected Influences on Alcohol Use in Pregnancy.International journal of environmental research and public health · 2025
    Review
  9. Article
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  11. Substance use and use disorders during pregnancy and the postpartum period.American journal of obstetrics and gynecology · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Meaghan ThumathCentre for Gender & Sexual Health Equity, 1081 Burrard Street, Vancouver BC, Canada; Department of Social Policy and Intervention, University of Oxford, Barnett House, 32 -37 Wellington Square, Oxford OX1 2ER; University of British Columbia, School of Nursing, T201-2211 Wesbrook Mall, Vancouver, BC Canada V6T 2B5. Electronic address: Meaghan.thumath@cgshe.ubc.ca.
David HumphreysDepartment of Social Policy and Intervention, University of Oxford, Barnett House, 32 -37 Wellington Square, Oxford OX1 2ER.
Jane BarlowDepartment of Social Policy and Intervention, University of Oxford, Barnett House, 32 -37 Wellington Square, Oxford OX1 2ER.
Putu DuffCentre for Gender & Sexual Health Equity, 1081 Burrard Street, Vancouver BC, Canada.
Melissa BraschelCentre for Gender & Sexual Health Equity, 1081 Burrard Street, Vancouver BC, Canada.
Brittany BinghamCentre for Gender & Sexual Health Equity, 1081 Burrard Street, Vancouver BC, Canada; Vancouver Coastal Health, Aboriginal Health, 2750 E. Hastings Street, Vancouver, BC.
Sophie PierreʔAq̓am, St. Mary's Indian Band, Ktunaxa Nation, 7470 Mission road, Cranbrook, B.C., V1C 7E5.
Kate ShannonCentre for Gender & Sexual Health Equity, 1081 Burrard Street, Vancouver BC, Canada; Department of Medicine, University of British Columbia, St. Paul's Hospital, 608-1081 Burrard Street, Vancouver, BC, Canada V6Z 1Y6.
University of Oxford · GBOxford Policy Management · GBSt. Paul's Hospital · CAVancouver Coastal Health · CA

Funding

Social and structural context of HIV/STI risk among FSWsR01DA028648 · NIDA · UNIVERSITY OF BRITISH COLUMBIA · PI GOLDENBERG, SHIRA MIRIAM, KRUSI, ANDREA · 2010 to 2024
$6.9M
Social and structural violence and HIV care continuum outcomes: Developing a trauma-informed HIV care intervention among WLWHR01MH123349 · NIMH · UNIVERSITY OF BRITISH COLUMBIA · PI DEERING, KATHLEEN, SHANNON, KATE · 2021 to 2025
$2.4M
CIHR HHP-98,835NIDA NIH HHS R01 DA028648NIMH NIH HHS R01 MH123349
6 · The paper itself

Abstract

backgroundAccidental overdose is a major public health concern in North America with research primarily focused on cisgender men. Little is known about the burden of overdose among marginalised women, particularly in the context of child custody loss. This study aims to examine the prevalence of overdose and the association with child removal in a cohort of marginalised women.

methodsThis study draws on a merged dataset (2010-2018) of two community-based longitudinal cohorts of over 1000 marginalised women in Canada recruited using time-location sampling. After restricting to women who had ever had a live birth, bivariate and multivariable logistic regression using generalised estimating equations (GEE) were used to examine the association between child removal and overdose. Joint effects of child removal and Indigeneity were also investigated.

resultsOf the 696 women who reported ever having a live birth, 39.7% (n = 276) reported child removal at baseline. Unintended, non-fatal overdose rates were high, with 35.1% (n = 244) of women reporting ever having an overdose. Using bivariate GEE analyses, having a child apprehended and being Indigenous were positively correlated with overdose. Using multivariable GEE, child removal increased the odds of overdose by 55% (AOR: 1.55; 95% CI 1.01-2.39) after adjusting for education and Indigenous ancestry. Using multivariable joint-effects analysis, Indigenous women who had experienced child removal had over twice the odds of an unintended overdose than non-Indigenous women who had not lost custody after adjusting for education, food insecurity, and sex work (AOR: 2.09; 95% CI 1.15-3.79).

conclusionThis analysis suggests that, after controlling for known confounders, women who have a child removed experience higher odds of overdose, and these odds are highest among Indigenous women. The high prevalence of overdose in this cohort suggests the need for further strategies to prevent overdose among pregnant and parenting women.

Indexed as

Drug OverdoseMothersCanadaChildFemaleHumansMaleNorth AmericaPregnancyProspective StudiesCanadaChild welfareMaternal healthOverdoseSubstance use

Identifiers

PMID33129662
PMCPMC8081759
OpenAlexW3097651688

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.