ArticlePsychiatry research. Neuroimaging2021
Examination of structural brain changes in recent suicidal behavior.
Article in Psychiatry research. Neuroimaging, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 15 citations in OpenAlex.
- Functional dysconnectivity in reward-related circuits in adolescents with major depressive disorder with and without suicidal ideation.CNS spectrums · 2026Article
- Psychoneuroimmunoendocrinological and neuroanatomical basis of suicidal behavior: potential therapeutic strategies with a focus on transcranial magnetic stimulation (TMS).Brain, behavior, & immunity - health · 2025Article
- 'Unravelling the shared genetic architecture between suicidality and subcortical brain volume: a genome-wide association study'.Acta neuropsychiatrica · 2025Article
- Aberrant glutamatergic systems underlying impulsive behaviors: Insights from clinical and preclinical research.Progress in neuro-psychopharmacology & biological psychiatry · 2024Review
- Identifying behaviour-related and physiological risk factors for suicide attempts in the UK Biobank.Nature human behaviour · 2024Article
- History of suicide attempt associated with amygdala and hippocampus changes among individuals with schizophrenia.European archives of psychiatry and clinical neuroscience · 2023Article
- Biological Factors Underpinning Suicidal Behaviour: An Update.Brain sciences · 2023Review
- Brain grey and white matter structural associations withJCPP advances · 2022Article
- Dissecting pain processing in adolescents with Non-Suicidal Self Injury: Could suicide risk lurk among the electrodes?European journal of pain (London, England) · 2021Article
- The Elusive Phenotype of Preadolescent Suicidal Thoughts and Behaviors: Can Neuroimaging Deliver on Its Promise?The American journal of psychiatry · 2021Article
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Authors and funding
6 authors at 4 institutions in 1 country.
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Abstract
We aimed to identify brain structural changes in cortical and subcortical regions linked to recent suicidal behavior. We performed secondary analyses of structural MRI data of two independent studies, namely the Establishing Moderators/Biosignatures of Antidepressant Response - Clinical Care (EMBARC) study and a Little Rock study on acute suicidal behavior. Study 1 (EMBARC, N = 187), compared individuals with remote suicide attempts (Remote-SA), individuals with lifetime suicide ideation but no attempts (Lifetime-SI only), and depressed individuals without lifetime suicide ideation or attempts (non-suicidal depressed). Study 2 (Little Rock data, N = 34) included patients recently hospitalized for suicide ideation or attempt constituted by: patients who recently attempted suicide (Recent-SA), individuals with remote suicide attempts (Remote-SA), and Lifetime-SI only. Study 3 combined the EMBARC and Little Rock datasets including Recent-SA, Remote-SA, Lifetime-SI only and non-suicidal depressed individuals. In Study 1 and Study 2, no significant differences were observed between groups. In Study 3, significantly lower middle temporal gyrus thickness, insular surface area, and thalamic volume and higher volume in the nucleus accumbens were observed in Recent-SA. This pattern of structural abnormalities may underlie pain and emotion dysregulation, which have been linked to the transition from suicidal thoughts to action.
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