ArticleImmunity2020
Orthogonal SARS-CoV-2 Serological Assays Enable Surveillance of Low-Prevalence Communities and Reveal Durable Humoral Immunity.
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Article in Immunity, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 220 papers.
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220citing papers in PubMed
8.4field-weighted citation impact, top 2% of its field
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Who cites it
220 citing papers in PubMed, 356 citations in OpenAlex.
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- Transmission matrix parameter estimation of COVID-19 evolution with age compartments using ensemble-based data assimilation.PloS one · 2025Article
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- Humoral waning kinetics against SARS-CoV-2 is dictated by disease severity and vaccine platform.medRxiv : the preprint server for health sciences · 2024Article
- Hybrid Immunity and SARS-CoV-2 Antibodies: Results of the HEROES-RECOVER Prospective Cohort Study.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2024Article
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- Epidemiological contemplation for a currently pragmatic COVID-19 health passport: a perspective.Frontiers in public health · 2024Review
- Serum antibody fingerprinting of SARS-CoV-2 variants in infected and vaccinated subjects by label-free microarray biosensor.Frontiers in immunology · 2024Article
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- Trends in SARS-CoV-2 seroprevalence among pregnant women attending first antenatal care visits in Zambia: A repeated cross-sectional survey, 2021-2022.PLOS global public health · 2024Article
- Serum per- and polyfluoroalkyl substance concentrations and longitudinal change in post-infection and post-vaccination SARS-CoV-2 antibodies.Environmental research · 2023Article
- Persistence of SARS-CoV-2-antibodies against N, S and RBD after natural infection.Iranian journal of microbiology · 2023Article
160 more citing papers are in PubMed but not listed here.
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Authors and funding
37 authors at 2 institutions in 1 country.
Tyler J RippergerDepartment of Immunobiology, University of Arizona College of Medicine, Tucson, Tucson, AZ, USA.
Jennifer L UhrlaubDepartment of Immunobiology, University of Arizona College of Medicine, Tucson, Tucson, AZ, USA; University of Arizona Center on Aging, University of Arizona College of Medicine, Tucson, Tucson, AZ, USA.
Makiko WatanabeDepartment of Immunobiology, University of Arizona College of Medicine, Tucson, Tucson, AZ, USA; University of Arizona Center on Aging, University of Arizona College of Medicine, Tucson, Tucson, AZ, USA.
Rachel WongDepartment of Immunobiology, University of Arizona College of Medicine, Tucson, Tucson, AZ, USA; Division of Biological and Biomedical Sciences, Washington University, St. Louis, MO, USA.
Yvonne CastanedaDepartment of Immunobiology, University of Arizona College of Medicine, Tucson, Tucson, AZ, USA; University of Arizona Center on Aging, University of Arizona College of Medicine, Tucson, Tucson, AZ, USA.
Hannah A PizzatoDepartment of Immunobiology, University of Arizona College of Medicine, Tucson, Tucson, AZ, USA; Division of Biological and Biomedical Sciences, Washington University, St. Louis, MO, USA.
Mallory R ThompsonDepartment of Surgery, University of Arizona College of Medicine, Tucson, Tucson, AZ, USA; Department of Cellular and Molecular Medicine, University of Arizona College of Medicine, Tucson, Tucson, AZ, USA.
Christine BradshawDepartment of Immunobiology, University of Arizona College of Medicine, Tucson, Tucson, AZ, USA; University of Arizona Center on Aging, University of Arizona College of Medicine, Tucson, Tucson, AZ, USA.
Craig C WeinkaufDepartment of Surgery, University of Arizona College of Medicine, Tucson, Tucson, AZ, USA.
Christian BimeDivision of Pulmonary, Allergy, Critical Care and Sleep Medicine, Department of Medicine, University of Arizona College of Medicine, Tucson, Tucson, AZ, USA.
Heidi L EricksonDivision of Pulmonary, Allergy, Critical Care and Sleep Medicine, Department of Medicine, University of Arizona College of Medicine, Tucson, Tucson, AZ, USA.
Kenneth KnoxDivision of Pulmonary, Allergy, Critical Care and Sleep Medicine, Department of Medicine, University of Arizona College of Medicine, Tucson, Tucson, AZ, USA; Department of Medicine, University of Arizona, Phoenix, Phoenix, AZ, USA.
Billie BixbyDivision of Pulmonary, Allergy, Critical Care and Sleep Medicine, Department of Medicine, University of Arizona College of Medicine, Tucson, Tucson, AZ, USA.
Sairam ParthasarathyDivision of Pulmonary, Allergy, Critical Care and Sleep Medicine, Department of Medicine, University of Arizona College of Medicine, Tucson, Tucson, AZ, USA.
Sachin ChaudharyDivision of Pulmonary, Allergy, Critical Care and Sleep Medicine, Department of Medicine, University of Arizona College of Medicine, Tucson, Tucson, AZ, USA.
Bhupinder NattDivision of Pulmonary, Allergy, Critical Care and Sleep Medicine, Department of Medicine, University of Arizona College of Medicine, Tucson, Tucson, AZ, USA.
Elaine CristanDivision of Pulmonary, Allergy, Critical Care and Sleep Medicine, Department of Medicine, University of Arizona College of Medicine, Tucson, Tucson, AZ, USA.
Tammer El AiniDivision of Pulmonary, Allergy, Critical Care and Sleep Medicine, Department of Medicine, University of Arizona College of Medicine, Tucson, Tucson, AZ, USA.
Franz RischardDivision of Pulmonary, Allergy, Critical Care and Sleep Medicine, Department of Medicine, University of Arizona College of Medicine, Tucson, Tucson, AZ, USA.
Janet CampionDivision of Pulmonary, Allergy, Critical Care and Sleep Medicine, Department of Medicine, University of Arizona College of Medicine, Tucson, Tucson, AZ, USA.
Madhav ChopraDivision of Pulmonary, Allergy, Critical Care and Sleep Medicine, Department of Medicine, University of Arizona College of Medicine, Tucson, Tucson, AZ, USA.
Michael InselDivision of Pulmonary, Allergy, Critical Care and Sleep Medicine, Department of Medicine, University of Arizona College of Medicine, Tucson, Tucson, AZ, USA.
Afshin SamDivision of Pulmonary, Allergy, Critical Care and Sleep Medicine, Department of Medicine, University of Arizona College of Medicine, Tucson, Tucson, AZ, USA.
James L KneplerDivision of Pulmonary, Allergy, Critical Care and Sleep Medicine, Department of Medicine, University of Arizona College of Medicine, Tucson, Tucson, AZ, USA.
Andrew P CapaldiDepartment of Molecular and Cellular Biology, University of Arizona, Tucson, Tucson, AZ, USA; Functional Genomics Core, University of Arizona, Tucson, AZ, USA.
Catherine M SpierDepartment of Pathology, University of Arizona College of Medicine, Tucson, Tucson, AZ, USA.
Michael D DakeOffice of the Senior Vice-President for Health Sciences, University of Arizona, Tucson, AZ, USA.
Taylor EdwardsUniversity of Arizona Genomics Core and the Arizona Research Labs, University of Arizona Genetics Core, University of Arizona, Tucson, AZ, USA.
Matthew E KaplanFunctional Genomics Core, University of Arizona, Tucson, AZ, USA.
Serena Jain ScottDivision of Geriatrics, General Medicine and Palliative Care, Department of Medicine, University of Arizona College of Medicine, Tucson, Tucson, AZ, USA.
Cameron HypesDivision of Pulmonary, Allergy, Critical Care and Sleep Medicine, Department of Medicine, University of Arizona College of Medicine, Tucson, Tucson, AZ, USA; Department of Emergency Medicine, University of Arizona College of Medicine, Tucson, Tucson, AZ, USA.
Jarrod MosierDivision of Pulmonary, Allergy, Critical Care and Sleep Medicine, Department of Medicine, University of Arizona College of Medicine, Tucson, Tucson, AZ, USA; Department of Emergency Medicine, University of Arizona College of Medicine, Tucson, Tucson, AZ, USA.
David T HarrisDepartment of Immunobiology, University of Arizona College of Medicine, Tucson, Tucson, AZ, USA; University of Arizona Health Sciences Biobank, University of Arizona, Tucson, AZ, USA.
Bonnie J LaFleurBIO5 Institute, University of Arizona, Tucson, AZ, USA.
Ryan SprisslerUniversity of Arizona Genomics Core and the Arizona Research Labs, University of Arizona Genetics Core, University of Arizona, Tucson, AZ, USA; BIO5 Institute, University of Arizona, Tucson, AZ, USA.
Janko Nikolich-ŽugichDepartment of Immunobiology, University of Arizona College of Medicine, Tucson, Tucson, AZ, USA; University of Arizona Center on Aging, University of Arizona College of Medicine, Tucson, Tucson, AZ, USA; BIO5 Institute, University of Arizona, Tucson, AZ, USA. Electronic address: nikolich@arizona.edu.
Deepta BhattacharyaDepartment of Immunobiology, University of Arizona College of Medicine, Tucson, Tucson, AZ, USA; BIO5 Institute, University of Arizona, Tucson, AZ, USA. Electronic address: deeptab@arizona.edu.
University of Arizona · USUniversity of Phoenix · US
Funding
TRANSCRIPTIONAL REGULATION OF ANTIBODY RESPONSES AND IMMUNITYR01AI099108 · NIAID · WASHINGTON UNIVERSITY · PI Deepta Bhattacharya · 2012 to 2026
$6.4MGLUCOSE AND AMINO ACID CATABOLISM IN PLASMA CELL BIOLOGYR01AI129945 · NIAID · UNIVERSITY OF ARIZONA · PI Deepta Bhattacharya · 2018 to 2026
$4.8MT Cell Homeostasis and Function in Immune SenescenceR37AG020719 · NIA · UNIVERSITY OF ARIZONA · PI JANKO Z. NIKOLICH · 2018 to 2026
$4.2MViral burden and systemic inflammation as biomarkers for chronic disease and frailty in agingU01AG060900 · NIA · INDIANA UNIVERSITY INDIANAPOLIS · PI NIKOLICH, JANKO Z., TWIGG, HOMER L · 2018 to 2022
$3.5MT Cell Homeostasis and Function in Immune SenescenceR01AG020719 · NIA · UNIVERSITY OF ARIZONA · PI NIKOLICH, JANKO Z. · 2001 to 2012
$3.1MInfection and Inflammation as Drivers of Aging (IIDA) Predoctoral Training ProgramT32AG058503 · NIA · UNIVERSITY OF ARIZONA · PI Kristian Paul Doyle, JANKO Z. NIKOLICH · 2019 to 2026
$1.9MMechanisms of age-related susceptibility to the chikungunya virus (CHIKV)R01AG057701 · NIA · UNIVERSITY OF ARIZONA · PI NIKOLICH, JANKO Z. · 2018 to 2022
$1.7MSELPLG as a candidate gene in Acute Respiratory Distress SyndromeK08HL141623 · NHLBI · UNIVERSITY OF ARIZONA · PI BIME, CHRISTIAN · 2018 to 2022
$863kNHLBI NIH HHS K08 HL141623NIAID NIH HHS R01 AI099108NIAID NIH HHS R01 AI129945NIA NIH HHS R01 AG020719NIA NIH HHS R01 AG057701NIA NIH HHS R37 AG020719NIA NIH HHS T32 AG058503NIA NIH HHS U01 AG060900
Abstract
We conducted a serological study to define correlates of immunity against SARS-CoV-2. Compared to those with mild coronavirus disease 2019 (COVID-19) cases, individuals with severe disease exhibited elevated virus-neutralizing titers and antibodies against the nucleocapsid (N) and the receptor binding domain (RBD) of the spike protein. Age and sex played lesser roles. All cases, including asymptomatic individuals, seroconverted by 2 weeks after PCR confirmation. Spike RBD and S2 and neutralizing antibodies remained detectable through 5-7 months after onset, whereas α-N titers diminished. Testing 5,882 members of the local community revealed only 1 sample with seroreactivity to both RBD and S2 that lacked neutralizing antibodies. This fidelity could not be achieved with either RBD or S2 alone. Thus, inclusion of multiple independent assays improved the accuracy of antibody tests in low-seroprevalence communities and revealed differences in antibody kinetics depending on the antigen. We conclude that neutralizing antibodies are stably produced for at least 5-7 months after SARS-CoV-2 infection.
Indexed as
Immunity, HumoralAdolescentAdultAgedAged, 80 and overAntibodies, NeutralizingAntibodies, ViralArizonaBetacoronavirusClinical Laboratory TechniquesCoronavirus InfectionsCoronavirus Nucleocapsid ProteinsCOVID-19COVID-19 TestingFemaleHumansAntibodies, NeutralizingAntibodies, ViralCoronavirus Nucleocapsid Proteinsnucleocapsid phosphoprotein, SARS-CoV-2Nucleocapsid ProteinsPhosphoproteinsSpike Glycoprotein, Coronavirusspike protein, SARS-CoV-2antibodiesCOVID-19neutralizationnucleocapsid proteinorthogonal serological testsreceptor binding domainS2 domainSARS-CoV-2serological testserologyspike protein
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