Evidence map›Paper›PMID 33129333›Full record

ReviewJournal of nanobiotechnology2020

State-of-the-art polymeric nanoparticles as promising therapeutic tools against human bacterial infections.

Amanda Cano, Miren Ettcheto, Marta Espina, Ana López-Machado, Yolanda Cajal, Francesc Rabanal, Elena Sánchez-López, Antonio Camins, Maria Luisa García, Eliana B Souto

Registry-linked trialAbstract readReview
In one paragraph

Review in Journal of nanobiotechnology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06106659 (Comparison of Clinical Outcomes of Mini Midline Catheters With Different Placement Sites), which is not on this map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06106659 nacompletednot on this mapstarted 2023, after this paper: background citation

Comparison of Clinical Outcomes of Mini Midline Catheters With Different Placement Sites: a Randomized Controlled Trial

TypeinterventionalSponsorSir Run Run Shaw HospitalRan2023 to 2024Enrolled130ConditionsCatheter ComplicationsArmsMini Midline
3 · Its place in the literature

Who cites it

29 citing papers in PubMed.

  1. Review
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  3. Article
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  5. Article
  6. Review
  7. Review
  8. Review
  9. Article
  10. Review
  11. Review
  12. RSC advances · 2025
    Review
  13. Review
  14. Review
  15. Article
  16. Article
  17. Review
  18. Structural modification of theMicrobiology (Reading, England) · 2023
    Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Amanda CanoDepartment of Pharmacy, Pharmaceutical Technology and Physical Chemistry, Faculty of Pharmacy and Food Sciences, University of Barcelona, Av Joan XXIII, 27-31, 08017, Barcelona, Spain. acanofernandez@ub.edu.
Miren EttchetoBiomedical Research Networking Centre in Neurodegenerative Diseases (CIBERNED), Madrid, Spain.
Marta EspinaDepartment of Pharmacy, Pharmaceutical Technology and Physical Chemistry, Faculty of Pharmacy and Food Sciences, University of Barcelona, Av Joan XXIII, 27-31, 08017, Barcelona, Spain.
Ana López-MachadoDepartment of Pharmacy, Pharmaceutical Technology and Physical Chemistry, Faculty of Pharmacy and Food Sciences, University of Barcelona, Av Joan XXIII, 27-31, 08017, Barcelona, Spain.
Yolanda CajalDepartment of Pharmacy, Pharmaceutical Technology and Physical Chemistry, Faculty of Pharmacy and Food Sciences, University of Barcelona, Av Joan XXIII, 27-31, 08017, Barcelona, Spain.
Francesc RabanalSection of Organic Chemistry, Department of Inorganic and Organic Chemistry, Faculty of Chemistry, University of Barcelona, Barcelona, Spain.
Elena Sánchez-LópezDepartment of Pharmacy, Pharmaceutical Technology and Physical Chemistry, Faculty of Pharmacy and Food Sciences, University of Barcelona, Av Joan XXIII, 27-31, 08017, Barcelona, Spain.
Antonio CaminsBiomedical Research Networking Centre in Neurodegenerative Diseases (CIBERNED), Madrid, Spain.
Maria Luisa GarcíaDepartment of Pharmacy, Pharmaceutical Technology and Physical Chemistry, Faculty of Pharmacy and Food Sciences, University of Barcelona, Av Joan XXIII, 27-31, 08017, Barcelona, Spain.
Eliana B SoutoDepartment of Pharmaceutical Technology, Faculty of Pharmacy, University of Coimbra, Coimbra, Portugal.

Funding

Fundació la Marató de TV3 201829-10Ministerio de Economía, Industria y Competitividad, Gobierno de España SAF2017-84283-R
6 · The paper itself

Abstract

Infectious diseases kill over 17 million people a year, among which bacterial infections stand out. From all the bacterial infections, tuberculosis, diarrhoea, meningitis, pneumonia, sexual transmission diseases and nosocomial infections are the most severe bacterial infections, which affect millions of people worldwide. Moreover, the indiscriminate use of antibiotic drugs in the last decades has triggered an increasing multiple resistance towards these drugs, which represent a serious global socioeconomic and public health risk. It is estimated that 33,000 and 35,000 people die yearly in Europe and the United States, respectively, as a direct result of antimicrobial resistance. For all these reasons, there is an emerging need to find novel alternatives to overcome these issues and reduced the morbidity and mortality associated to bacterial infectious diseases. In that sense, nanotechnological approaches, especially smart polymeric nanoparticles, has wrought a revolution in this field, providing an innovative therapeutic alternative able to improve the limitations encountered in available treatments and capable to be effective by theirselves. In this review, we examine the current status of most dangerous human infections, together with an in-depth discussion of the role of nanomedicine to overcome the current disadvantages, and specifically the most recent and innovative studies involving polymeric nanoparticles against most common bacterial infections of the human body.

Indexed as

AnimalsAnti-Bacterial AgentsBacterial InfectionsBiomimetic MaterialsDrug CompoundingHumansNanocapsulesNanomedicineNeisseria meningitidisPolymersSkinAnti-Bacterial AgentsNanocapsulesPolymersBacterial infectionsInfectious diseasesNanomedicineNanotechnologyPolymeric nanoparticles

Identifiers

PMID33129333
PMCPMC7603693

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.