ArticleJournal of translational medicine2020
Association of hypertension and hypertriglyceridemia on incident hyperuricemia: an 8-year prospective cohort study.
Article in Journal of translational medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed.
- Previous schistosome infection and the risk of incident hyperuricemia: A prospective cohort study.PLoS neglected tropical diseases · 2026Article
- Assisted evaluation of aniline'sRSC advances · 2026Article
- Association between the Zhejiang University index and hyperuricemia among adults with type 2 diabetes in China.Frontiers in endocrinology · 2026Article
- Hyperuricemia Is Independently Associated With Hyperlipidemia in a Large Population-Based Study.Journal of clinical laboratory analysis · 2025Article
- Associations between estimated glucose disposal rate and hyperuricemia in patients with type 2 diabetes mellitus: a cross-sectional study.BMC nephrology · 2025Article
- Estimated glucose disposal rate and risk of incident hyperuricemia: insights from CHARLS.Scientific reports · 2025Article
- Metabolic dysfunction-associated fatty liver disease and the risk of gout: a UK Biobank prospective cohort study.European journal of medical research · 2025Article
- Effects of thyroid-stimulating hormone and sensitivity to thyroid hormones on the risk of hyperuricemia in euthyroid adults.Archives of endocrinology and metabolism · 2025Observational
- Metabolic subtypes in hypertriglyceridemia and associations with diseases: insights from population-based metabolome atlas.Journal of translational medicine · 2025Article
- Sex-specific associations between blood urea nitrogen and risk of hyperuricemia in U.S. adults: the NHANES 1999-2020.Frontiers in endocrinology · 2025Article
- Association between the triglyceride-glucose index and hyperuricemia: potential role of obesity in patients with Type 2 diabetes mellitus.Frontiers in endocrinology · 2025Article
- Remnant Cholesterol as a Superior Marker Over LDL-C for Hyperuricemia: A Cross-Sectional Study in Northwest China.Diabetes, metabolic syndrome and obesity : targets and therapy · 2025Article
- Genetic Commonalities Between Metabolic Syndrome and Rheumatic Diseases Through Disease Interactome Modules.Journal of cellular and molecular medicine · 2025Article
- Association between Body Mass Index and Serum Uric Acid: mediation analysis involving liver enzymes indicators.BMC public health · 2024Article
- Remnant cholesterol elevates hyperuricemia risk in the middle aged and elderly Chinese: a longitudinal study.Scientific reports · 2024Article
- Elevated blood pressure and hyperuricemia risk: a retrospective cohort study from Wuhu, China.Scientific reports · 2024Article
- The relationship between non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio (NHHR) and hyperuricaemia.Lipids in health and disease · 2024Article
- Article
- Review
- Dyslipidemia and hyperuricemia: a cross-sectional study of residents in Wuhu, China.BMC endocrine disorders · 2024Article
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHypertension and high triglyceride are two of the most important risk factors for hyperuricemia. Epidemiological records show that hypertension and dyslipidemia often coexist and may significantly increase the risk of target organ damage. However, their combined effect on incident hyperuricemia is poorly understood. Thus, we aimed to investigate the separate and combined effect of hypertension and hypertriglyceridemia on the incidence of hyperuricemia.
methodsA prospective cohort study of 6424 hyperuricemia-free participants aged 20 to 94 years between August 2009 and October 2017 was performed at Tianjin General Hospital of China. Participants were categorized into four groups by combining hypertension and hypertriglyceridemia status at baseline. The restricted cubic spline fitting Cox regression model was used to evaluate the relationship between blood pressure and triglyceride and hyperuricemia. Cox regression models were performed to calculate hazard ratios (HRs) and 95% confident intervals (CIs) to estimate baseline factors and their association with the incidence of hyperuricemia. A Kaplan-Meier survival analysis was performed to compare the incidence of hyperuricemia among subjects in each separate and combined hypertension and hypertriglyceridemia group.
resultsDuring the 8-year follow-up period, 1259 subjects developed hyperuricemia (20.6%). There existed positive relationships between blood pressure and triglyceride levels and hyperuricemia. This risk factor arising from a combination of the two (HR, 3.02; 95% CI 2.60-3.50) is greater than that from hypertension (HR, 1.48; 95% CI 1.28-1.71) or hypertriglyceridemia (HR, 1.84; 95% CI 1.55-2.18) separately. The Kaplan-Meier survival analysis indicated that combined effect of hypertension and hypertriglyceridemia may predict higher onset of hyperuricemia.
conclusionThe combined effect of hypertension and hypertriglyceridemia on the risk of hyperuricemia is much stronger than that by hypertension or hypertriglyceridemia separately. Hypertension combined with hypertriglyceridemia may be an independent and powerful predictor for hyperuricemia.
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