Evidence map›Paper›PMID 33129312›Full record

ArticleBMC nephrology2020

Independent associations of urinary albumin-to-creatinine ratio and serum cystatin C with carotid intima-media thickness in community-living Taiwanese adults.

Chiu-Shong Liu, Chia-Ing Li, Yuh-Cherng Guo, Chih-Hsueh Lin, Wen-Yuan Lin, Chung-Hsiang Liu, Mu-Cyun Wang, Chuan-Wei Yang, Shing-Yu Yang, Tsai-Chung Li and 1 more

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In one paragraph

Article in BMC nephrology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.4field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Chiu-Shong LiuSchool of Medicine, College of Medicine, China Medical University, Taichung, Taiwan.
Chia-Ing LiSchool of Medicine, College of Medicine, China Medical University, Taichung, Taiwan.
Yuh-Cherng GuoDepartment of Neurology, China Medical University Hospital, Taichung, Taiwan.
Chih-Hsueh LinSchool of Medicine, College of Medicine, China Medical University, Taichung, Taiwan.
Wen-Yuan LinSchool of Medicine, College of Medicine, China Medical University, Taichung, Taiwan.
Chung-Hsiang LiuDepartment of Neurology, China Medical University Hospital, Taichung, Taiwan.
Mu-Cyun WangSchool of Medicine, College of Medicine, China Medical University, Taichung, Taiwan.
Chuan-Wei YangDepartment of Medical Research, China Medical University Hospital, Taichung, Taiwan.
Shing-Yu YangDepartment of Public Health, College of Public Health, China Medical University, 91 Hsueh-Shih Road, Taichung, 40421, Taiwan.
Tsai-Chung LiDepartment of Public Health, College of Public Health, China Medical University, 91 Hsueh-Shih Road, Taichung, 40421, Taiwan. tcli@mail.cmu.edu.tw.ORCID 0000-0002-3346-7462
Cheng-Chieh LinSchool of Medicine, College of Medicine, China Medical University, Taichung, Taiwan.
China Medical University · TWAsia University · TW

Funding

China Medical University CMU108-AWARD-02Ministry of Science and Technology, Taiwan MOST 104-2314-B-039-016, MOST 105-2314-B-039-021-MY3, MOST 105-2314-B-039-025-MY3, MOST 107-2314-B-039-049, MOST 108-2314-B-039-039, MOST 108-2314-B-039-035-MY3 and MOST 108-2314-B-039-031-MY2
6 · The paper itself

Abstract

backgroundRenal function is a key factor of cardiovascular disease. Carotid intima-media thickness (IMT) has been widely used as a marker of early subclinical atherosclerosis. The determinants of cystatin C, a novel marker of renal function, have not been extensively studied in the Asian population. This study aimed to assess the determinants of cystatin C and explore whether carotid thickening was associated with urinary albumin-creatinine ratio and cystatin C in community-living Taiwanese adults.

methodsA cross-sectional study was conducted on participants from Taichung City, Taiwan. All the participants underwent carotid ultrasonography. Carotid IMT-mean and IMT-maximum were derived. Kidney biomarkers were measured on the basis of urinary albumin-to-creatinine ratio (ACR) and cystatin C. Multiple linear regression analysis was used.

resultsA total of 1032 individuals were recruited, and 469 (45.44%) of them were men. An increased cystatin C level was significantly associated with older age, male gender, lack of physical activity, low HDL cholesterol, abdominal obesity, high hs-CRP, and high ACR. The multivariate-adjusted mean carotid IMT-mean and IMT-maximum values significantly increased by 80.49 and 195.23 μm for every one unit of increase in cystatin C level and by 0.07 and 0.14 μm for every one unit of increase in ACR, respectively (all p < 0.001 except ACR on IMT-maximum with p < 0.01). Lack of physical activity, low HDL, abdominal obesity, high hs-CRP, and high ACR were the determinants of cystatin C.

conclusionCystatin C and ACR were strongly and linearly associated with carotid thickening, a marker of subclinical atherosclerosis.

Indexed as

AlbuminuriaCarotid Intima-Media ThicknessAgedAged, 80 and overAtherosclerosisBiomarkersCarotid ArteriesCreatinineCross-Sectional StudiesCystatin CFemaleHeart Disease Risk FactorsHumansMaleMiddle AgedTaiwanBiomarkersCreatinineCystatin CAlbumin-to-creatinine ratioCreatinineCystatin CIntima-media thickness

Identifiers

PMID33129312
PMCPMC7603773
OpenAlexW3094722462

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.